2026-04-17T15:56:30Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/255462025-12-05T10:07:18Zcom_2072_1057col_2072_478917col_2072_478929

Calbindin D-28K and parvalbumin immunoreactivity in the frontal cortex in patients with frontal lobe dementia of non-Alzheimer type associated with amyotrophic lateral sclerosis Ferrer, Isidro (Ferrer Abizanda) Tuñón, Teresa Serrano Piñol, M. Teresa Casas, Rosaura Alcántara Horrillo, Soledad Zújar, M. J. Rivera, R. M. Esclerosi lateral amiotròfica Lòbul frontal Demència Amyotrophic lateral sclerosis Frontal lobe Dementia The morphology and distribution of local-circuit neurons (interneurons) were examined, by calbindin D-28k and parvalbumin immunocytochemistry, in the frontal cortex (area 8) in two patients with frontal lobe dementia of non-Alzheimer type associated with classical amyotrophic lateral sclerosis (ALS), and in seven normal cases. The density of calbindin D-28k immunoreactive cells was dramatically reduced in ALS patients, but the density of parvalbumin-immunoreactive neurons was preserved. Decreased density of calbindin D-28k-immunoreactive neurons, which are mainly located in the upper cortical layers, may interfere with the normal processing of cortico-cortical connections, whereas integrity of parvalbumin-immunoreactive cells may be associated with the preservation of the major inhibitory intracortical circuits in patients with frontal lobe dementia. 2012-05-14T10:37:07Z 2012-05-14T10:37:07Z 1993 info:eu-repo/semantics/article 0022-3050 https://hdl.handle.net/2445/25546 92192 8459241 eng Reproducció del document publicat a: http://dx.doi.org/10.1136/jnnp.56.3.257 Journal of Neurology Neurosurgery and Psychiatry, 1993, num. 56, p. 257-261 http://dx.doi.org/10.1136/jnnp.56.3.257 (c) British Medical Journal, 1993 info:eu-repo/semantics/openAccess 5 p. application/pdf BMJ Publishing Group Articles publicats en revistes (Patologia i Terapèutica Experimental)