2026-04-18T02:52:43Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2286202026-04-10T23:01:46Zcom_2072_1057col_2072_478798col_2072_478916col_2072_478917

urn:hdl:2445/228620 Association between arsenic levels in toenails and urine and prostate cancer risk: Findings from the MCC-Spain study Fernández Navarro, Pablo Pollán, Marina Pérez Gómez, Beatriz García Esquinas, Esther Varea-Jiménez, Elena Pastor-Barriuso, Roberto Sierra, Maria Angeles Dierssen Sotos, Trinidad Fernández Tardón, Guillermo Aragonès Sanz, Núria Gómez Acebo, Inés Castaño-Vinyals, Gemma Gómez Ariza, José Luis Kogevinas, Manolis Moreno Aguado, Víctor Marcadors tumorals Càncer de pròstata Compostos d'arsènic Tumor markers Prostate cancer Arsenic compounds Background: Arsenic (As) is a toxic metalloid widely distributed in the environment. Chronic exposure to As has been associated with the development of several types of cancer. However, its role in prostate cancer (PC) remains unclear. Objective: To evaluate the relationship between As exposure and the risk of PC, considering different clinical tumour classifications and genetic susceptibility, and to compare biomarkers that may reflect distinct exposure windows. Methods: We included 345 incident cases and 468 controls with available data on both urinary and toenail As concentrations within the MCC-Spain project. Toenail and urinary As levels were measured using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES), respectively. Genetic susceptibility was assessed using a polygenic risk score (PRS) based on SingleNucleotide Polymorphisms. Associations between As exposure and PC were examined using mixed-effects and multinomial logistic regression models. Results: Higher toenail As concentrations were associated with increased risk of PC [odds ratio (OR) comparing the fourth to first quartile: 1.94; 95 % confidence interval (CI):1.23–3.06]. Stratified analyses by tumor classification showed consistent risk increases for advanced and aggressive tumors [ISUP3-5 Relative risk ratio (RRR) quartile 4vs.1: 2.86 (1.16–7.06); AJCC IIB-IV RRR: 2.58 (1.48–4.50); cT2-cT4 RRR: 3.05 (1.55–5.99)]. No clear association was found with urinary As concentrations. Interaction analyses showed no evidence of effect modification by PRS. 2026-03-31T07:15:22Z 2026-03-31T07:15:22Z 2026-03-15 2026-03-31T07:15:23Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.1016/j.envres.2026.123767 Environmental Research, 2026, vol. 293 https://doi.org/10.1016/j.envres.2026.123767 cc-by-nc (c) Fernández Navarro, Pablo et al., 2026 https://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess Elsevier Articles publicats en revistes (Ciències Clíniques)