2026-04-04T04:59:30Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/2285972026-03-31T13:44:03Zcom_2072_1057col_2072_478861col_2072_478916col_2072_478917
RECERCAT
author
Ulsamer, Arnau
author
Betbesé Roig, Antoni Jordi
author
Campos Gómez, Ana
author
Centelles Serra, Josep Joan
author
Domínguez, Eduardo
author
Iglesias i Serret, Daniel
author
Lorente Olazábal, Juan V.
author
Pérez Fernández, Xosé Luis
author
Sabater Riera, Joan
author
Rigo Bonnin, Raúl
author
Kellum, John A.
2026-03-31T13:44:02Z
2026-03-31T13:44:02Z
2026-03-30T13:11:04Z2026-03-30T13:11:04Z2025-11-262026-03-30T13:11:06Z
https://hdl.handle.net/2445/228597
There is a widespread belief that organic sodium salts included in intravenous solutions serve as bicarbonate precursors, and that this mechanism explains their effects on plasma pH. We aimed to explain why the effect of organic anions, such as citrate, acetate, gluconate, and lactate on the acid-base balance is independent of bicarbonate generation. For this purpose, we mainly focused on regional citrate anticoagulation (RCA). The sodium load provided with these buffers and its contribution to the plasma strong ion difference is a more suitable model for explaining and predicting their alkalinizing effect. Moreover, the bicarbonate generated from the metabolization of these buffers via the Krebs cycle results from CO2 dissolution in water, and thus yields bicarbonate together with a proton (H+). As such, metabolization of these buffers does not cause alkalosis per se.
cc-by (c) Ulsamer, Arnau et al., 2025 http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
Bicarbonat de sodi
Intermediaris (Química)
Sodium bicarbonate
Intermediates (Chemistry)
Buffers in intravenous solutions: is the source of bicarbonate a source of confusion?
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion