2026-04-03T21:12:09Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2285972026-03-31T13:44:03Zcom_2072_1057col_2072_478861col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Ulsamer, Arnau author Betbesé Roig, Antoni Jordi author Campos Gómez, Ana author Centelles Serra, Josep Joan author Domínguez, Eduardo author Iglesias i Serret, Daniel author Lorente Olazábal, Juan V. author Pérez Fernández, Xosé Luis author Sabater Riera, Joan author Rigo Bonnin, Raúl author Kellum, John A. author 2026-03-30T13:11:04Z 2026-03-30T13:11:04Z 2025-11-26 2026-03-30T13:11:06Z There is a widespread belief that organic sodium salts included in intravenous solutions serve as bicarbonate precursors, and that this mechanism explains their effects on plasma pH. We aimed to explain why the effect of organic anions, such as citrate, acetate, gluconate, and lactate on the acid-base balance is independent of bicarbonate generation. For this purpose, we mainly focused on regional citrate anticoagulation (RCA). The sodium load provided with these buffers and its contribution to the plasma strong ion difference is a more suitable model for explaining and predicting their alkalinizing effect. Moreover, the bicarbonate generated from the metabolization of these buffers via the Krebs cycle results from CO2 dissolution in water, and thus yields bicarbonate together with a proton (H+). As such, metabolization of these buffers does not cause alkalosis per se. https://hdl.handle.net/2445/228597 Bicarbonat de sodi Intermediaris (Química) Sodium bicarbonate Intermediates (Chemistry) Buffers in intravenous solutions: is the source of bicarbonate a source of confusion?