2026-04-03T21:11:45Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2285972026-03-31T13:44:03Zcom_2072_1057col_2072_478861col_2072_478916col_2072_478917

2026-03-31T13:44:02Z urn:hdl:2445/228597 Buffers in intravenous solutions: is the source of bicarbonate a source of confusion? Ulsamer, Arnau Betbesé Roig, Antoni Jordi Campos Gómez, Ana Centelles Serra, Josep Joan Domínguez, Eduardo Iglesias i Serret, Daniel Lorente Olazábal, Juan V. Pérez Fernández, Xosé Luis Sabater Riera, Joan Rigo Bonnin, Raúl Kellum, John A. Bicarbonat de sodi Intermediaris (Química) Sodium bicarbonate Intermediates (Chemistry) There is a widespread belief that organic sodium salts included in intravenous solutions serve as bicarbonate precursors, and that this mechanism explains their effects on plasma pH. We aimed to explain why the effect of organic anions, such as citrate, acetate, gluconate, and lactate on the acid-base balance is independent of bicarbonate generation. For this purpose, we mainly focused on regional citrate anticoagulation (RCA). The sodium load provided with these buffers and its contribution to the plasma strong ion difference is a more suitable model for explaining and predicting their alkalinizing effect. Moreover, the bicarbonate generated from the metabolization of these buffers via the Krebs cycle results from CO2 dissolution in water, and thus yields bicarbonate together with a proton (H+). As such, metabolization of these buffers does not cause alkalosis per se. 2026-03-31T13:44:02Z 2026-03-31T13:44:02Z 2026-03-30T13:11:04Z 2026-03-30T13:11:04Z 2025-11-26 2026-03-30T13:11:06Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://hdl.handle.net/2445/228597 Reproducció del document publicat a: https://doi.org/10.1186/s13054-025-05780-2 Critical Care, 2025, vol. 29 https://doi.org/10.1186/s13054-025-05780-2 cc-by (c) Ulsamer, Arnau et al., 2025 http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess BioMed Central