2026-04-13T13:36:13Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2285812026-04-07T18:04:08Zcom_2072_1057col_2072_478858col_2072_478917col_2072_478921

urn:hdl:2445/228581 Report of three azole-resistant Aspergillus fumigatus cases with TR34/L98H mutation in hematological patients in Barcelona; Spain. Monzó Gallo, Patricia Alastruey Izquierdo, Ana Chumbita, Mariana Aiello, Tommaso Francesco Gallardo Pizarro, Antonio Peyrony, Olivier Teijon Lumbreras, Christian Alcázar Fuoli, Laura Espasa, Mateu Soriano Viladomiu, Alex Marco Reverté, Francesc García Vidal, Carolina Malalties hematològiques Mutació (Biologia) Infeccions oportunistes Hematologic diseases Mutation (Biology) Opportunistic infections Objectives We aimed to report the emergence of azole-resistant invasive aspergillosis in hematologic patients admitted to a tertiary hospital in Spain during the last 4 months. Methods Prospective, descriptive study was performed to describe and follow all consecutive proven and probable invasive aspergillosis resistant to azoles from hematological cohort during the last 4 months. All patients had fungal cultures and antifungal susceptibility or real-time PCR detection for Aspergillus species and real-time PCR detection for azole-resistant mutation. Results Four cases of invasive aspergillosis were diagnosed in 4 months. Three of them had azole-resistant aspergillosis. Microbiological diagnosis was achieved in three cases by means of fungal culture isolation and subsequent antifungal susceptibility whereas one case was diagnosed by PCR-based aspergillus and azole resistance detection. All the azole-resistant aspergillosis presented TR34/L98H mutation. Patients with azole-resistant aspergillosis had different hematologic diseases: multiple myeloma, lymphoblastic acute leukemia, and angioimmunoblastic T lymphoma. Regarding risk factors, one had prolonged neutropenia, two had corticosteroids, and two had viral co-infection. Two of the patients developed aspergillosis under treatment with azoles. Conclusion We have observed a heightened risk of azole-resistant aspergillosis caused by A. fumigatus harboring the TR34/L98H mutation in patients with hematologic malignancies. The emergence of azole-resistant aspergillosis raises concerns for the community, highlighting the urgent need for increased surveillance and the importance of susceptibility testing and new drugs development. 2026-03-27T18:37:01Z 2026-03-27T18:37:01Z 2024-05-27 2026-03-27T18:37:01Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.1007/s15010-024-02236-7 Infection, 2024, vol. 52, p. 1651-1656 https://doi.org/10.1007/s15010-024-02236-7 cc-by (c) Monzó Gallo, Patricia et al., 2024 http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Springer Verlag Articles publicats en revistes (Medicina)