2026-04-13T06:59:37Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/2285662026-04-08T14:28:43Zcom_2072_1057col_2072_478821col_2072_478902col_2072_478917col_2072_478933
RECERCAT
author
Muñoz López, José María
author
Hu, Lei
author
Wang, Haomin
author
Tian, Xiaohe
author
Ruiz-Perez, Lorena
author
Battaglia, Giuseppe
2026-03-27T11:00:31Z2026-03-27T11:00:31Z2026-02-232026-03-27T11:00:32Z
We describe the creation of an amphiphilic triblock copolymer that drives lateral phase separation within micelle coronas. The design combines a hydrophobic poly(lactide) (PLA) core ‑forming block with two distinct hydrophilic segments: poly(ethylene glycol) (PEG) and poly( N ‑vinylpyrrolidone) (PVP). In water, the copolymer assembles into spherical micelles, confirmed by cryogenic TEM and multi ‑angle light scattering. Selective end ‑labelling of PVP with an electron ‑dense iridium complex enabled unstained TEM imaging, revealing clear contrast asymmetry that locates PVP to a single hemisphere of the corona. Complementary 2D1 H-Nuclear Overhauser Effect Spectroscopy (1 H ‑NOESY) NMR confirmed this Janus ‑type segregation of PEG and PVP. These results demonstrate how molecular architecture can encode asymmetry into soft nanostructures, offering a versatile route to polymer ‑based Janus nanoparticles with dual surface functionality and broad technological potential.
cc-by-nc-nd (c) Muñoz López, José María et al., 2026 https://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess
Col·loides
Copolímers
Polímers hidrosolubles
Colloids
Copolymers
Water-soluble polymers
Hydrophilic Janus Micelles from an ABC Triblock Copolymer
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion