2026-04-13T05:45:52Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/2281272026-04-08T14:08:16Zcom_2072_1057col_2072_478916col_2072_478917
RECERCAT author Barahona López, Cristina author Plans Beriso, Elena author Diez Echave, Paul author Hernández, Orlando author Fernández de Larrea, Nerea author Craciun, Oana author García Ovejero, Ester author Petrova, Dafina author Fernández Martínez, Nicolás Francisco author Arruabarrena Blanco, Estíbaliz author Babb de Villiers, Chantal author Turner, Heather author Cierco Jimenez, Ramon author Erady, Chaitanya author Wilson, Hayley author Fernández Navarro, Pablo author García García-Esquinas, Esther author Kuhn, Isla author Sánchez Juan, Pascual author Rodríguez-Artalejo, Fernando author Sánchez Pérez, María José author Moreno Aguado, Víctor author Blackburn, Laura author Pollán, Marina author Kroese, Mark author Pérez Gómez, Beatriz 2026-03-16T12:05:27Z2026-03-16T12:05:27Z2025-12-012026-02-05T10:32:59Z Neurodegenerative diseases represent a major public health challenge due to their high prevalence and poor prognosis. Identifying biomarkers to stratify individuals by their risk of developing these diseases may help to define new personalized prevention interventions. The objective of this study was to conduct a scoping review of biomarkers for primary and secondary personalized prevention of neurodegenerative diseases. The search targeted biomarkers in adults or high-risk subpopulations in clinical or public health settings for Alzheimer's disease, vascular dementia, Lewy body disease, frontotemporal dementia, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis. Ultimately, 286 papers were included in the review and the interactive gap map. There is a strong focus on Alzheimer's disease, and most papers included -omics-based biomarkers and/or used artificial intelligence. Genetics/genomics are at the forefront of current scientific research, although there is a notable gap in studying gene-environment interactions, and studies in clinical settings are still scarce.Highlights Research indicates a strong focus on Alzheimers disease and limited research in other diseases. Genetics and genomics are at the forefront of current scientific research. We found biomarkers for predicting progression in mild cognitive decline. There is a notable gap in studying gene-environment interactions. Studies investigating biomarkers in a clinical context are still scarce. cc-by-nc (c) Barahona López, Cristina et al., 2025 http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess Malalties neurodegeneratives Salut pública Neurodegenerative Diseases Public health Personalized prevention of neurodegenerative diseases: scoping review and evidence gap map info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion