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                  <mods:namePart>Torres-Novellas, Berta</mods:namePart>
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                  <mods:namePart>Guayta, Rafael (Guayta Escolies)</mods:namePart>
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                  <mods:namePart>Rius, Pilar</mods:namePart>
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                  <mods:namePart>Castellà, Amparo</mods:namePart>
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                  <mods:namePart>Gascón Lecha, M. Pilar</mods:namePart>
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                  <mods:namePart>Modamio Charles, Pilar</mods:namePart>
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                  <mods:namePart>Mariño Hernández, Eduardo L.</mods:namePart>
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                  <mods:dateIssued encoding="iso8601">2026-01-27T10:05:55Z2026-01-27T10:05:55Z20212026-01-27T10:05:55Z</mods:dateIssued>
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               <mods:abstract>The prevalence of elderly patients with chronic illnesses, associated polypharmacy and a high risk of functional and cognitive impairment has increased in recent&lt;/p>&lt;p>years. The care of Complex Chronic Patients (CCP) therefore represents a challenge for health systems in developed countries around the world. This paper presents&lt;/p>&lt;p>a study protocol that will explore the effects of an intervention within a pharmaceutical care programme (PCAF) on optimising CCP care and on the suitability of&lt;/p>&lt;p>the organisational methods proposed for the PCAF programme.&lt;/p>&lt;p>This is a multicentre experimental study. The setting will be primary health care and community pharmacies in the so-called ‘autonomous community’ of Catalonia&lt;/p>&lt;p>in Spain. The participants will be CPP attended to Primary Healthcare Centres with the CCP code in their electronic medical record. The included CCP will be&lt;/p>&lt;p>distributed in two strata depending on whether they will be considered likely to receive the arranged medicinal treatment as Monitored Dosage System according&lt;/p>&lt;p>to benefits based on criteria or not. They will then be assigned by random stratified sampling at a ratio of 1:1 to the control or intervention groups. A sample size of&lt;/p>&lt;p>860 patients is estimated. Patients will undergo 12 months follow-up. The primary outcome of this study will be the medication adherence measured by the Morisky&lt;/p>&lt;p>Green Test and the billing/prescription ratio.</mods:abstract>
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               <mods:accessCondition type="useAndReproduction">cc-by (c)  Torres-Novellas, B. et al., 2021 http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess</mods:accessCondition>
               <mods:subject>
                  <mods:topic>Malalties cròniques</mods:topic>
               </mods:subject>
               <mods:subject>
                  <mods:topic>Atenció farmacèutica</mods:topic>
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               <mods:subject>
                  <mods:topic>Chronic diseases</mods:topic>
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               <mods:subject>
                  <mods:topic>Pharmacy practice</mods:topic>
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                  <mods:title>A study protocol for an experimental study for a pharmaceutical care programme to improve chronic complex disease management: PCAF programme</mods:title>
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