2026-04-17T17:31:20Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2256482026-04-07T22:59:46Zcom_2072_1057col_2072_478813col_2072_478913col_2072_478917

00925njm 22002777a 4500 dc Proost, Sebastian author Vich Vila, Arnau author Raes, Jeroen author Vanhaecke, Lynn author De Boevre, Marthe author De Saeger, Sarah author Nawrot, Tim S. author Poma, Giulia author Covaci, Adrian author Ouden, Fatima den author Cseresznye, Adam author Engelen, Liesa author Maris, Elias author Bosschaerts, Stijn author Gys, Celine author Cleys, Paulien author Ait Bamai, Yu author Peró Gascón, Roger author Hemeryck, Lieselot Y. author Paepe, Ellen De author 2026-01-16T15:35:45Z 2026-01-01 2026-01-16T15:35:45Z info:eu-repo/date/embargoEnd/2027-12-31 Humans are exposed daily to contaminants such as organophosphorus flame retardants (PFRs), legacy plasticizers (LPs), and alternative plasticizers (APs). To date, most biomonitoring studies in children have only focused on analysis of LP metabolites and a subset of PFRs and APs. This study investigated exposure to multiple PFRs, LPs and APs in the ENVIR<em>ON</em>AGE birth cohort quantifying 13 PFR metabolites in 655 urine samples, while we measured 8 LP and 13 AP metabolites in urine of 328 children. For PFRs, more than 50% of children were exposed to TNBP, TPHP, TDCIPP, TCIPP and EHDPHP. More than 93% of children were exposed to the measured LPs (DEP, DiBP, DnBP, BBzP and DEHP), while for APs more than 50% of children showed exposure to DEHA, DEHTP, DINCH and DIDP. Concentrations of PFR metabolites were higher in summer, while the presence of a pet in the house was associated with higher LP metabolite concentrations. Risk characterization ratios (RCRs) for single compounds and hazard indices (HIs) for compound classes suggested no risk for adverse health effects due to PFR exposure. For LPs, two children showed a HI above 1, while for APs, ten children had a HI above 1. The results indicate widespread exposure to PFRs and plasticizers, with most children being exposed to levels that are considered safe. However, the current study confirms a shift in exposure from LPs to APs, implying the need for further research on exposure to multiple APs in future studies. Plastificants Retardants de flama Avaluació del risc Plasticizers Fireproofing agents Risk assessment Chemical exposure in childhood: A. study on organophosphate flame retardants and plasticizers