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oai:recercat.cat:2445/2250212026-04-08T16:13:05Zcom_2072_1057col_2072_478858col_2072_478916col_2072_478913col_2072_478917col_2072_478921

Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort Matía-Martín, Pilar Shyam, Sangeetha García Gavilán, Jesús Paz-Graniel, Indira Gaforio, José J. Martínez-González, Miguel Ángel, 1957- Corella Piquer, Dolores Martínez Hernández, José Alfredo Alonso Gómez, Ángel M. Wärnberg, Julia Vioque, Jesús Romaguera, Dora López-Miranda, José Estruch Riba, Ramon Tinahones, Francisco José Lapetra, José Serra-Majem, Lluís Bueno-Cavanillas, Aurora Tur, Josep Antoni Martín-Sánchez, V. Pintó Sala, Xavier Vidal i Cortada, Josep Vázquez, Clotilde Daimiel, Lidia Ros Rahola, Emilio Fernández Aranda, Fernando Nishi, Stephanie K Garcia-Regata, Oscar Toledo, Estefanía Asensio, Eva M Castañer Niño, Olga Garcia-Rios, Antonio Torres-Collado, Laura Gómez Gracia, Enrique Zulet, M. Angeles Goñi Ruiz, Nuria Casas Rodríguez, Rosa M. Cano Ibáñez, Naomi Tojal Sierra, Lucas Gómez-Perez, AM Sorlí, José V Cinza-Sanjurjo, Sergio Martín-Peláez, Sandra Peña-Orihuela, Patricia J Oncina-Canovas, Alejandro Perez-Araluce, Rafael Zomeño, Maria Dolores Chaplin, Alice Delgado Rodriguez, Miguel Babio, Nancy Fitó Colomer, Montserrat Salas-Salvadó, Jordi Obesitat Vellesa COVID-19 Obesity Old age COVID-19 Background: Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk. Methods: This analysis included 6874 men and women (aged 55-75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5-6 years before the pandemic and their changes at the visit prior to censoring. Results: At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk. Conclusions: In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19. 2025-12-17T10:20:08Z 2025-12-17T10:20:08Z 2023-10-13 2025-12-17T10:20:08Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 1741-7015 https://hdl.handle.net/2445/225021 741158 37833678 eng Reproducció del document publicat a: https://doi.org/10.1186/s12916-023-03079-z BMC Medicine, 2023, vol. 21, num.1 https://doi.org/10.1186/s12916-023-03079-z cc-by (c) Shyam S et al., 2023 http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess 13 p. application/pdf BioMed Central Articles publicats en revistes (Medicina)