2026-04-19T16:10:07Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2250212026-04-08T16:13:05Zcom_2072_1057col_2072_478858col_2072_478916col_2072_478913col_2072_478917col_2072_478921

00925njm 22002777a 4500 dc Matía-Martín, Pilar author Shyam, Sangeetha author García Gavilán, Jesús author Paz-Graniel, Indira author Gaforio, José J. author Martínez-González, Miguel Ángel, 1957- author Corella Piquer, Dolores author Martínez Hernández, José Alfredo author Alonso Gómez, Ángel M. author Wärnberg, Julia author Vioque, Jesús author Romaguera, Dora author López-Miranda, José author Estruch Riba, Ramon author Tinahones, Francisco José author Lapetra, José author Serra-Majem, Lluís author Bueno-Cavanillas, Aurora author Tur, Josep Antoni author Martín-Sánchez, V. author Pintó Sala, Xavier author Vidal i Cortada, Josep author Vázquez, Clotilde author Daimiel, Lidia author Ros Rahola, Emilio author Fernández Aranda, Fernando author Nishi, Stephanie K author Garcia-Regata, Oscar author Toledo, Estefanía author Asensio, Eva M author Castañer Niño, Olga author Garcia-Rios, Antonio author Torres-Collado, Laura author Gómez Gracia, Enrique author Zulet, M. Angeles author Goñi Ruiz, Nuria author Casas Rodríguez, Rosa M. author Cano Ibáñez, Naomi author Tojal Sierra, Lucas author Gómez-Perez, AM author Sorlí, José V author Cinza-Sanjurjo, Sergio author Martín-Peláez, Sandra author Peña-Orihuela, Patricia J author Oncina-Canovas, Alejandro author Perez-Araluce, Rafael author Zomeño, Maria Dolores author Chaplin, Alice author Delgado Rodriguez, Miguel author Babio, Nancy author Fitó Colomer, Montserrat author Salas-Salvadó, Jordi author 2025-12-17T10:20:08Z 2025-12-17T10:20:08Z 2023-10-13 2025-12-17T10:20:08Z Background: Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk. Methods: This analysis included 6874 men and women (aged 55-75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5-6 years before the pandemic and their changes at the visit prior to censoring. Results: At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk. Conclusions: In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19. Obesitat Vellesa COVID-19 Obesity Old age COVID-19 Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort