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oai:recercat.cat:2445/2249732026-04-07T22:46:31Zcom_2072_1057col_2072_478916col_2072_478917

Generation of the induced pluripotent stem cell line ESi108-A from a familial atrial fibrillation patient Martínez Moreno, Rebecca Pérez Serra, Alexandra Selga, Elisabet Carreras, David Aran, Begoña Kuebler, Bernd Scornik, Fabiana S. Pérez, Guillermo J. Brugada, Ramon Epigènesi Patologia cel·lular Cèl·lules mare embrionàries Epigenesis Cellular pathology Embryonic stem cells Tissue-specific cells differentiated from patient-derived human induced pluripotent stem cells (hiPSC) are a relevant cellular model to study several diseases. We obtained a hiPSC line from skin fibroblasts of a patient affected by familial atrial fibrillation by nucleofection of non-integrating episomal vectors. The resulting hiPSC line displays a normal karyotype, expresses pluripotency surface markers and pluripotency genes, and differentiates into cells of the 3 germ layers. Therefore, it represents a reliable model to study the disease in a physiologically relevant cellular environment. 2025-12-16T11:38:24Z 2025-12-16T11:38:24Z 2023-10-31 2025-12-05T11:44:12Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 1873-5061 https://hdl.handle.net/2445/224973 37922745 eng Reproducció del document publicat a: https://doi.org/10.1016/j.scr.2023.103239 Stem Cell Research, 2023, vol. 73 https://doi.org/10.1016/j.scr.2023.103239 cc-by (c) Martínez Moreno, Rebecca et al., 2023 https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess 4 p. application/pdf Elsevier BV Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))