2026-04-19T19:17:39Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2249692026-04-08T13:56:00Zcom_2072_1057col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Bernal Labrador, Eva author Romaguera, Rafael author García Blas, Sergio author Regueiro, Ander author Serra, Vicenç author Asmarats, Lluís author Tizón Marcos, Helena author Agudelo, Víctor author Scardino, Claudia author Casanova Sandoval, Juan Manuel author Rodríguez Gabella, Tania author Jiménez Méndez, César author Pérez Rivera, Ángel author Robles Gamboa, Carolina author Ayesta, Ana author Díez Villanueva, Pablo author Raposeiras Roubín, Sergio author Amat Santos, Ignacio J. author Esteve Pastor, Asunción author Veiga Fernández, Gabriela author Anguita, Manuel author Martí Sánchez, David author Martínez Velilla, Nicolás author Cortés, Laia author Calvo, Elena author Asimbaya, Steven author Formiga, Francesc author Ariza Solé, Albert author 2025-12-16T11:01:58Z 2025-12-16T11:01:58Z 2025-06-10 2025-12-09T14:35:29Z Introduction and objectives: Although transcatheter aortic valve implantation (TAVI) is the first-line therapy for aortic stenosis (AS), its benefit could be lower (or even disappear) in frail patients. Physical exercise and nutritional support programs are recommended to address frailty. Data on the application of telemedicine strategies in this context is scarce. The objective of this study is to analyze, in older patients with AS undergoing TAVI, the effect of a telematic intervention on the reversal of frailty vs standard of care. Methods: We will be conducting a randomized multicenter study including patients aged >= 75 years with severe AS (mean aortic gradient > 40 mmHg, or aortic valve area < 0.8 8 cm2 on echocardiogram) with baseline frailty criteria (Short Physical Performance Battery [SPPB ] < 10 and FRAIL scale >= 3) undergoing TAVI. Prior to discharge, patients will be randomized to a) a telematic intervention within the first 3 months (nutritional support plus supervised physical exercise plus health education); or b) standard of care. The primary endpoint will be the percentage of patients with frailty reversal (SPPB >= 10) at 3 months. The estimated sample size is 206 patients (103 in each arm). Conclusions: The hypothesis of this study is that telematic intervention will allow a higher percentage of frailty reversal at 3 months vs standard of care after TAVI. The results of this study may provide novel information on this approach to frail patients with AS undergoing TAVI. ClinicalTrials.gov registered trial (NCT06742970). Telemàtica mèdica Telecomunicació en medicina Telepatia Medical telematics Telecommunication in medicine Telepathy Intervención telemática sobre la fragilidad en pacientes tratados con TAVI. Diseño del ensayo clínico TELE-FRAIL TAVI