2026-04-19T09:24:56Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2249592026-04-08T14:31:33Zcom_2072_1057col_2072_478816col_2072_478917

Towards a glutathione-cleavable azobenzene linker for antibody–drug conjugates Kapun, Mia Patel, Roshan Park, Mahri Pérez Areales, Francisco Javier Kostadinova, Kristina A. Wharton, Thomas Carroll, Jason S. Spring, David R. Fotofarmacologia Síntesi de pèptids Estrès oxidatiu Glutatió Photopharmacology Peptide synthesis Oxidative stress Glutathione Herein we describe the development of a novel azobenzene-containing glutathione-cleavable linker for use in antibody–drug conjugates (ADCs). This linker demonstrated efficient payload release under elevated glutathione levels while maintaining stability in human plasma. An anti-HER2 ADC incorporating this linker exhibited potent <em>in vitro</em> cytotoxicity and selective activity towards HER2-positive cell lines. 2025-12-16T08:33:44Z 2025-12-16T08:33:44Z 2025-10-28 2025-12-16T08:33:44Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 1359-7345 https://hdl.handle.net/2445/224959 762928 eng Reproducció del document publicat a: https://doi.org/10.1039/D5CC05824D Chemical Communications, 2025, vol. 61, p. 18902-18905 https://doi.org/10.1039/D5CC05824D cc-by (c) Mia Kapun et al., 2025 http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess 4 p. application/pdf Royal Society of Chemistry Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)