2026-04-05T12:53:11Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/2247222025-12-06T21:44:43Zcom_2072_1057col_2072_478917col_2072_478931
RECERCAT author Serra Navarro, Maria author Clougher, Derek author Oliva, Vincenzo author Valenzuela-Pascual, Clàudia author De Prisco, Michele author Forte, Maria Florencia author Garriga, Marina author Solé Cabezuelo, Brisa author Sánchez-Moreno, José author Verdolini, Norma author Menculini, Giulia author Tortorella, Alfonso author Bernardo Arroyo, Miquel author Ramos-Quiroga, Josep Antoni author Martínez-Arán, Anabel, 1971- author Vieta i Pascual, Eduard, 1963- author Amoretti Guadall, Silvia author Torrent Font, Carla 2025-12-06T21:44:42Z 2025-12-06T21:44:42Z 2025-12-05T14:03:41Z2025-12-05T14:03:41Z2025-03-052025-12-05T14:03:41Z http://hdl.handle.net/2445/224722 Introduction: Impairment in both psychosocial functioning and neurocognition (NC) performance is present in bipolar disorder (BD) yet the role of sex differences in these deficits remains unclear. The present systematic review and meta-analysis examined whether males and females with BD demonstrate differences in psychosocial functioning and NC performance. Methods: The Cochrane Library, EMBASE, PsycINFO, PubMed, Scopus, and Web of Science databases were systematically searched from inception until November 20, 2023. Results: Twenty studies published between 2005 and 2023 with a total sample size of 2286 patients with BD were included. A random effects meta-analysis revealed a statistically significant result with a small effect (SMD = 0.313) for sex differences in verbal learning and memory as well as visual learning and memory (SMD = 0.263). Females outperformed males in both domains. No significant sex differences were observed for any other NC outcome or psychosocial functioning. High heterogeneity and differences in assessment scales used should be considered when interpreting these findings, given their potential impact on results. Conclusions: Future research should adopt a more homogenous, standardized approach using longitudinal designs to gain a clearer insight nto sex differences in this population. This approach so may increase the use of preventative therapeutic options to address the difficult clinical challenge of reaching cognitive and functional recovery. cc-by (c) Serra Navarro, Maria et al., 2025 http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Trastorn bipolar Psicologia social Neuropsicologia clínica Cognició Diferències entre sexes Manic-depressive illness Social psychology Clinical neuropsychology Cognition Sex differences Sex differences in psychosocial functioning and neurocognition in bipolar disorder: A systematic review and meta-analysis info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion