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Immunoglobulin A and C reactive protein levels in ankylosing spondylitis Collado Cruz, Antonio Sanmartí Sala, Raimon Brancós Cunill, Ma. Antonia Kanterewicz Binstock, Eduardo Gallart, Teresa Rotés Querol, J. (Jaume), 1921-2008 Cobos Carbó, Albert Immunoglobulines Espondiloartritis anquilosant Immunoglobulins Ankylosing spondylitis Correspondence: SIR, We read with interest the recent paper by Sanders et al on the correlation of immunoglobulin and C reactive protein (CRP) levels in 22 patients with ankylosing spondylitis (AS) and 20 patients with rheumatoid arthritis (RA).' The authors found that IgA serum levels, though raised in AS, do not correlate with CRP levels as they do in RA, suggesting that the mechanism of increase of IgA in the two diseases may be different. They conclude that production of IgA in AS is unrelated to the stimulation of acute phase reactants, reflecting a specific mucosal immune stimulation, possibly in the gut. Thus IgA may be a marker of the pathogenesis of AS. 2012-03-05T12:52:24Z 2012-03-05T12:52:24Z 1987 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció digital del document publicat a: http://dx.doi.org/10.1136/ard.46.9.719 Annals of the Rheumatic Diseases, 1987, vol. 46, núm. 9, p. 719-720 http://dx.doi.org/10.1136/ard.46.9.719 (c) BMJ Publishing Group Ltd, 1987 info:eu-repo/semantics/openAccess BMJ Group Articles publicats en revistes (Medicina)