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oai:recercat.cat:2445/224592025-12-05T16:24:50Zcom_2072_1057col_2072_478917col_2072_478921

Antibodies to endothelial cells in Behçet's disease: cell-binding heterogeneity and association with clinical activity Cervera i Segura, Ricard, 1960- Navarro López, Margarita López-Soto, Alfonso Cid Xutglà, M. Cinta Font Franco, Josep, 1953-2006 Esparza Sánchez, Jordi Reverter Calatayud, Juan Carlos Monteagudo Terres, Juan Ingelmo Morín, Miguel Urbano Márquez, A. (Álvaro) Malaltia de Behçet Endoteli Autoanticossos Immunoglobulines Behçet's disease Endothelium Autoantibodies Immunoglobulins OBJECTIVES--To investigate the prevalence and characteristics of antibodies to endothelial cells (aEC) from large vessel and from microvasculature in a group of patients with Behçet's disease (BD) to determine the relationship of these antibodies with clinical and laboratory features of the disease. METHODS--Thirty patients with BD were prospectively and consecutively studied. The aEC were determined by enzyme-linked immunosorbent assay (ELISA) using endothelial cells derived from human umbilical vein (large vessel) as well as from retroperitoneal adipose tissue (microvasculature). RESULTS--Fifteen patients (50%) had aEC, either directed to large vessel [8(26%) patients] or microvascular [13(43%) patients] endothelial cells. The percentage of active patients was significantly higher in the aEC-positive group [12(80%) patients] compared with the aEC-negative group [5(33%) patients] (p < 0.05). CONCLUSIONS--Patients with BD have a high prevalence of aEC when microvascular endothelial cells are used in the assay. These antibodies seem to be a marker of disease activity in this condition, previously considered as negative for autoantibodies. 2012-03-05T12:52:14Z 2012-03-05T12:52:14Z 1994 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 0003-4967 https://hdl.handle.net/2445/22459 101197 8203957 25774787 eng Reproducció digital del document publicat a: http://dx.doi.org/10.1136/ard.53.4.265 Annals of the Rheumatic Diseases, 1994, vol. 53, núm. 4, p. 265-267 http://dx.doi.org/10.1136/ard.53.4.265 (c) BMJ Publishing Group Ltd, 1994 info:eu-repo/semantics/openAccess 3 p. application/pdf BMJ Group Articles publicats en revistes (Medicina)