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oai:recercat.cat:2445/224462025-11-21T05:34:46Zcom_2072_1057col_2072_478917col_2072_478921

Anti-chromatin antibodies in systemic lupus erythematosus: a useful marker for lupus nephropathy. Cervera i Segura, Ricard, 1960- Viñas i Folch, Octavi Ramos Casals, Manuel Font Franco, Josep, 1953-2006 García Carrasco, Mario Sisó Almirall, Antoni Ramírez, F. Machuca, Y. Vives i Corrons, Joan Lluís Ingelmo Morín, Miguel Burlingame, R. W. Lupus eritematós Malalties del ronyó Immunoglobulines Lupus erythematosus Kidney diseases Immunoglobulins Background: Anti-chromatin antibodies have recently been described in patients with systemic lupus erythematosus (SLE) and it has been suggested that their presence is associated with lupus nephritis. Objective: To assess the prevalence and clinical associations of these antibodies in SLE. Methods: The presence of anti-chromatin antibodies in 100 patients with SLE was investigated by an enzyme linked immunosorbent assay (ELISA). To determine the specificity of these antibodies, 100 patients with primary Sjögren’s syndrome, 30 with primary antiphospholipid syndrome (APS), 10 with systemic sclerosis, and 100 normal controls were also tested. Results: Positive levels were detected in 69/100 (69%) patients with SLE. In contrast, they were found in only 8/100 (8%) of those with primary Sjögren’s syndrome, in 1/10 (10%) with systemic sclerosis, in 2/30 (7%) with primary APS, and in none of the 100 healthy controls. Patients with anti-chromatin antibodies had a twofold higher prevalence of lupus nephropathy than those without these antibodies (58% v 29%, p<0.01). A significant correlation was found between the levels of anti-chromatin antibodies and disease activity score as measured by the European Consensus Lupus Activity Measurement (ECLAM; p=0.011). Conclusions: The measurement of anti-chromatin antibodies appears to be a useful addition to the laboratory tests that can help in the diagnosis and treatment of SLE. These antibodies are both sensitive and specific for SLE, and are a useful marker for an increased risk of lupus nephritis. 2012-03-05T12:52:09Z 2012-03-05T12:52:09Z 2003 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 0003-4967 https://hdl.handle.net/2445/22446 568771 12695155 eng Reproducció digital del document publicat a: http://dx.doi.org/10.1136/ard.62.5.431 Annals of the Rheumatic Diseases, 2003, vol. 62, núm. 5, p. 431-434 http://dx.doi.org/10.1136/ard.62.5.431 (c) BMJ Publishing Group Ltd, 2003 info:eu-repo/semantics/openAccess 4 p. application/pdf application/pdf BMJ Group Articles publicats en revistes (Medicina)