2026-04-17T14:28:39Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/2241532025-12-05T01:30:42Zcom_2072_1057col_2072_478917col_2072_478921
Sex-stratified mortality estimates in people with schizophrenia: A systematic review and meta-analysis of cohort studies of 2,700,825 people with schizophrenia
Høye, Anne
Koyanagi, Ai
Larsson, Henrik
Lehto, Kelli
Lindgren, Peter
Manchia, Mirko
Nordentoft, Merete
Skonieczna-Żydecka, Karolina
Stubbs, Brendon
Vancampfort, Davy
Bitter, István
Vieta i Pascual, Eduard, 1963-
Gorwood, Philip
De Prisco, Michele
Taipale, Heidi
Boyer, Laurent
Tiihonen, Jari
Højlund, Mikkel
Cortese, Samuele
Correll, Christoph U.
Dragioti, Elena
Rietz, Ebba Du
Nielsen, Rene Ernst
Firth, Joseph
Fusar-Poli, Paolo
Solmi, Marco
Croatto, Giovanni
Fabiano, Nicholas
Wong, Stanley
Gupta, Arnav
Fornaro, Michele
Schneider, Lynne Kolton
Rohani-Montez, S. Christy
Fairley, Leanne
Smith, Nathalie
Hartman, Catharina
Holt, Richard I. G.
Ressenyes sistemàtiques (Investigació mèdica)
Antipsicòtics
Mortalitat
Esquizofrènia
Metaanàlisi
Systematic reviews (Medical research)
Antipsychotic drugs
Mortality
Schizophrenia
Meta-analysis
The differential influence of sex on premature mortality in schizophrenia is unclear. This study assessed the differences in all-cause and specific cause mortality risks in people with schizophrenia compared to several control groups stratified by sex. Weconducted a PRISMA 2020-compliant systematic review and random-effects metaanalysis of cohort studies assessing mortality relative risk (RR) for people with schizophrenia, comparing by sex. We measured publication bias and conducted a quality assessment through the Newcastle-Ottawa scale. We meta analyzed 43 studies reporting on 2,700,825 people with schizophrenia. Both males and females with schizophrenia had increased all-cause mortality vs. comparison groups (males, RR=2.62, 95%CI 2.35-2.92; females, RR=2.56, 95%CI 2.27-2.87), suicide (males, RR=9.02, 95%CI 5.96-13.67; females, RR=12.09, 95%CI 9.00-16.25), and natural cause mortality (males, RR=2.11, 95%CI 1.88-2.38; females, RR=2.14, 95%CI 1.93-2.38). No statistically significant differences in sex-dependent mortality risk emerged. There was an age-group-dependent increased mortality risk in females < 40 years vs. >/=40 years old (RR=4.23/2.17), and significantly higher risk of death due to neurological disorders (dementia) in males vs. females (RR=5.19/2.40). Increased mortality risks were often associated with specific modifiable risk factors. There were minimal statistically significant differences in sex-dependent mortality risks in people with schizophrenia. However, it revealed areas of targeted intervention efforts.
2025-11-06T11:21:33Z
2025-11-06T11:21:33Z
2025-02-01
2025-11-06T11:21:33Z
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
Versió postprint del document publicat a: https://doi.org/10.1016/j.euroneuro.2024.11.001
European Neuropsychopharmacology, 2025, vol. 91, p. 56-66
https://doi.org/10.1016/j.euroneuro.2024.11.001
cc-by-nc-nd (c) Elsevier B.V., 2025
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
Elsevier B.V.
Articles publicats en revistes (Medicina)