2026-04-17T03:22:57Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/2241532025-12-05T01:30:42Zcom_2072_1057col_2072_478917col_2072_478921
RECERCAT author Høye, Anne author Koyanagi, Ai author Larsson, Henrik author Lehto, Kelli author Lindgren, Peter author Manchia, Mirko author Nordentoft, Merete author Skonieczna-Żydecka, Karolina author Stubbs, Brendon author Vancampfort, Davy author Bitter, István author Vieta i Pascual, Eduard, 1963- author Gorwood, Philip author De Prisco, Michele author Taipale, Heidi author Boyer, Laurent author Tiihonen, Jari author Højlund, Mikkel author Cortese, Samuele author Correll, Christoph U. author Dragioti, Elena author Rietz, Ebba Du author Nielsen, Rene Ernst author Firth, Joseph author Fusar-Poli, Paolo author Solmi, Marco author Croatto, Giovanni author Fabiano, Nicholas author Wong, Stanley author Gupta, Arnav author Fornaro, Michele author Schneider, Lynne Kolton author Rohani-Montez, S. Christy author Fairley, Leanne author Smith, Nathalie author Hartman, Catharina author Holt, Richard I. G. 2025-11-06T11:21:33Z2025-11-06T11:21:33Z2025-02-012025-11-06T11:21:33Z The differential influence of sex on premature mortality in schizophrenia is unclear. This study assessed the differences in all-cause and specific cause mortality risks in people with schizophrenia compared to several control groups stratified by sex. Weconducted a PRISMA 2020-compliant systematic review and random-effects metaanalysis of cohort studies assessing mortality relative risk (RR) for people with schizophrenia, comparing by sex. We measured publication bias and conducted a quality assessment through the Newcastle-Ottawa scale. We meta analyzed 43 studies reporting on 2,700,825 people with schizophrenia. Both males and females with schizophrenia had increased all-cause mortality vs. comparison groups (males, RR=2.62, 95%CI 2.35-2.92; females, RR=2.56, 95%CI 2.27-2.87), suicide (males, RR=9.02, 95%CI 5.96-13.67; females, RR=12.09, 95%CI 9.00-16.25), and natural cause mortality (males, RR=2.11, 95%CI 1.88-2.38; females, RR=2.14, 95%CI 1.93-2.38). No statistically significant differences in sex-dependent mortality risk emerged. There was an age-group-dependent increased mortality risk in females < 40 years vs. >/=40 years old (RR=4.23/2.17), and significantly higher risk of death due to neurological disorders (dementia) in males vs. females (RR=5.19/2.40). Increased mortality risks were often associated with specific modifiable risk factors. There were minimal statistically significant differences in sex-dependent mortality risks in people with schizophrenia. However, it revealed areas of targeted intervention efforts. cc-by-nc-nd (c) Elsevier B.V., 2025 http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Ressenyes sistemàtiques (Investigació mèdica) Antipsicòtics Mortalitat Esquizofrènia Metaanàlisi Systematic reviews (Medical research) Antipsychotic drugs Mortality Schizophrenia Meta-analysis Sex-stratified mortality estimates in people with schizophrenia: A systematic review and meta-analysis of cohort studies of 2,700,825 people with schizophrenia info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion