2026-04-17T14:10:30Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2235882025-12-04T19:32:03Zcom_2072_1057col_2072_478781col_2072_478908col_2072_478917

Dysregulation of the FGF21-adiponectin axis in a large cohort of patients with severe obesity and liver disease Castañé Vilafranca, Helena Jiménez Franco, Andrea Onoiu, Alina Iuliana Cambra Cortés, Vicente Hernández Aguilera, Anna Parada Domíngues, David Riu, Francisco Zorzano Olarte, Antonio Camps, Jordi Joven, Jorge Malalties del fetge Trastorns del metabolisme Liver diseases Disorders of metabolism We investigated the impact of liver damage on systemic inter-organ communication in an extensive observational case-control study of 923 patients with severe obesity and biopsy-confirmed metabolic dysfunction-associated steatotic liver disease (MASLD) or metabolic dysfunction-associated steatohepatitis (MASH) undergoing bariatric surgery. Using a comprehensive panel of circulating organokines, including fibroblast growth factor (FGF) 19, FGF21, adiponectin, galectin-3, irisin, and leptin, along with choline metabolites, we characterized metabolic signaling patterns associated with liver disease severity. Compared to controls, patients with MASLD/MASH exhibited significantly lower levels of FGF19, choline, and trimethylamine, while FGF21, galectin-3, irisin, and leptin were elevated. Sex-specific alterations in leptin and adiponectin were observed in patients with severe obesity but not in controls. Network analysis revealed a complex and individualized interplay among organokines, shaped by age, sex, and anthropometric factors. Despite this complexity, a dysregulation of the FGF21-adiponectin axis was associated with more advanced liver involvement. The large cohort and comprehensive organokine profiling studied provide valuable insights into the role of the FGF21-adiponectin axis on systemic metabolic alterations in severe obesity and their potential clinical implications. 2025-10-10T11:42:13Z 2025-10-10T11:42:13Z 2025-09-02 2025-10-09T10:37:16Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 1422-0067 https://hdl.handle.net/2445/223588 6747343 40943431 eng Reproducció del document publicat a: https://doi.org/10.3390/ijms26178510 International Journal of Molecular Sciences, 2025, vol. 26, num. 17, 8510 https://doi.org/10.3390/ijms26178510 cc-by (c) Castañé Vilafranca, Helena et al., 2025 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess 20 p. application/pdf MDPI Articles publicats en revistes (Bioquímica i Biomedicina Molecular)