2026-04-13T01:09:59Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/2233892025-12-04T22:40:32Zcom_2072_1057col_2072_478825col_2072_478917
RECERCAT author Carcereny, Albert author Arrebola, Alba author Chavarria Miró, Gemma author Castellarnau Serra, Montserrat de author Fuentes Pardo, Cristina author García-Pedemonte, David author Martínez-Velázquez, Adán author Ribes Mora, Enric author Bosch, Albert author Guix Arnau, Susana author Costafreda Salvany, M. Isabel (Maria Isabel) author Pintó Solé, Rosa María 2025-09-25T12:23:29Z2025-09-25T12:23:29Z2025-06-122025-09-25T12:23:30Z Hepatitis A virus (HAV) egresses from hepatocytes cloaked in exosomes (eHAV). However, the traffic network used for its release from polarized hepatocytes is not completely understood. We propose that eHAV biogenesis may follow not only an ESCRT-mediated pathway but also the syndecan-syntenin-ALIX pathway. The Bro1 and the V domains of ALIX bind to the pX extension of VP1 and the VP2-late domains of the unmature capsid, respectively. A Serine-to-Glycine replacement at position 134 of VP2, closely located with the first late domain, facilitates the interaction with ALIX promoting the syndecan-syntenin-ALIX pathway and improving the basolateral egress, preferentially using RAB35. This replacement is conserved in hepatoviruses infecting a wide range of mammalian species, but not in hepatoviruses infecting chimpanzees and humans. An inefficient basolateral egress could be a strategy to escape the antiviral cellular response in apes. cc-by-nc-nd (c) Albert Carcereny et al., 2025 https://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Cicles vitals (Biologia) Evolució (Biologia) Hepatitis vírica Life cycles (Biology) Evolution (Biology) Viral hepatitis The hepatocyte traffic network in the human hepatitis A virus biological cyclefrom an evolutionary perspective info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion