2026-04-17T05:16:36Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2228972026-03-13T19:39:12Zcom_2072_1057col_2072_478858col_2072_478906col_2072_478917col_2072_478921

00925njm 22002777a 4500 dc Fares Otero, Natalia Elena author Verdolini, Norma author Melero, Helena author Andrés Camazón, Pablo author Vilajosana, Enric author Cavone, Vito author García Bueno, Borja author Rapado Castro, Marta author Izquierdo, Ana author Martín Hernández, David author Mola Cárdenes, Pablo author Leal Leturia, Itziar author Dompablo Tobar, Mónica author Ortiz Tallo, Ana author Martínez Gras, Isabel author Muñoz Sanjose, Ainoa author Loeck de Lapuerta, Carmen author Rodriguez Jimenez, Roberto author Díaz-Marsá, Marina author Bravo Ortiz, María Fe author Ibáñez Cuadrado, Ángela author Baca García, Enrique author Vieta i Pascual, Eduard, 1963- author Ayuso Mateos, José Luis author Malpica, Norberto author Arango López, Celso author Díaz Caneja, Covadonga M. author Radua, Joaquim author 2025-09-02T11:30:46Z 2025-09-02T11:30:46Z 2024-12-16 2025-09-02T11:30:47Z Background Both childhood adversity (CA) and first-episode psychosis (FEP) have been linked to alterations in cortical thickness (CT). The interactive effects between different types of CAs and FEP on CT remain understudied. Methods One-hundred sixteen individuals with FEP (mean age = 23.8 ± 6.9 years, 34% females, 80.2% non-affective FEP) and 98 healthy controls (HCs) (mean age = 24.4 ± 6.2 years, 43% females) reported the presence/absence of CA <17 years using an adapted version of the Childhood Experience of Care and Abuse (CECA.Q) and the Retrospective Bullying Questionnaire (RBQ) and underwent magnetic resonance imaging (MRI) scans. Correlation analyses were used to assess associations between brain maps of CA and FEP effects. General linear models (GLMs) were performed to assess the interaction effects of CA and FEP on CT. Results Eighty-three individuals with FEP and 83 HCs reported exposure to at least one CA. CT alterations in FEP were similar to those found in participants exposed to separation from parents, bullying, parental discord, household poverty, and sexual abuse (r = 0.50 to 0.25). Exposure to neglect (β = −0.24, 95% CI [−0.37 to −0.12], p = 0.016) and overall maltreatment (β = −0.13, 95% CI [−0.20 to −0.06], p = 0.043) were associated with cortical thinning in the right medial orbitofrontal region. Conclusions Cortical alterations in individuals with FEP are similar to those observed in the context of socio-environmental adversity. Neglect and maltreatment may contribute to CT reductions in FEP. Our findings provide new insights into the specific neurobiological effects of CA in early psychosis. Psicosi en els infants Neuropsiquiatria pediàtrica Psychoses in children Pediatric neuropsychiatry Triangulating the associations of different types of childhood adversity and first-episode psychosis with cortical thickness across brain regions