2026-04-13T02:04:16Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2228462025-12-05T01:58:44Zcom_2072_1057col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Katzke, Verena author Dutta, Srimanti author Rasokat, Anna author Archibugi, Livia author Capurso, Gabriele author Peduzzi, Giulia author Gentiluomo, Manuel author Canzian, Federico author Eriksen, Anne Kirstine author Tjønneland, Anne author Dahm, Christina C. author Truong, Thérèse author Canonico, Marianne author Laouali, Nasser author Schulze, Matthias B. author Tumino, Rosario author Masala, Giovanna author Agnoli, Claudia author Dansero, Lucia author Panico, Salvatore author Crous Bou, Marta author Molina Montes, Esther author Dorronsoro, Ane author Chirlaque, María Dolores author Guevara, Marcela author Butt, Salma Tunå author Sund, Malin author Christakoudi, Sofia author Aglago, Elom K. author Weiderpass, Elisabete author Gunter, Marc J. author Campa, Daniele author Kaaks, Rudolf author 2025-08-29T12:07:49Z 2025-08-29T12:07:49Z 2025-07-08 2025-08-26T12:52:28Z Background/Objectives: Worldwide, men experience a higher incidence of pancreatic cancer (PC) than women. Methods: To increase understanding of the underlying reasons for this sex-related difference, we analysed general and sex-related risk factors for PC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (women/men No. = 293,682/136,728; 717/577 PC-cases). Results: Cox proportional hazards models showed a 1.31-fold higher risk of developing PC for men compared to women (HR, 95% CI 1.15-1.49) after adjustment for age, smoking history, BMI, diabetes, and alcohol consumption. Associations of PC with established risk factors did not differ between men and women, with the exception of a greater risk of PC among women with greater attained body height, meat consumption and cigarettes smoked (1.12 (1.05-1.19) per 5 cm, 1.18 (1.02-1.36) per 100 g/d, 1.42 (1.27-1.59) per 10/d; respectively). Among child-bearing women, long cumulative duration of breastfeeding was inversely associated with risk of PC (HR 0.74, 95% CI 0.61-0.89) for >5.7 months of breastfeeding (median) relative to <= 5.7 months and among HRT users, cumulative duration of HRT use was inversely associated with PC risk (HR 0.71, 95% CI 0.53-0.95, >2.4 versus <= 2.4 years). Further reproductive and hormonal factors, such as age at menarche, number of full-term pregnancies, age at menopause, or use of oral contraceptives, were not significantly associated with PC risk. Conclusions: Pooled analyses of large cohort studies are needed to confirm these results, and detailed data on the type and intensity of HRT are required to better evaluate its effect. Càncer de pàncrees Factors sexuals en les malalties Pancreas cancer Sex factors in disease Sex disparities and female reproductive and hormonal factors associated with risk of pancreatic cancer in the european prospective investigation into cancer and nutrition (EPIC) cohort