2026-04-13T00:08:47Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2228462025-12-05T01:58:44Zcom_2072_1057col_2072_478916col_2072_478917

urn:hdl:2445/222846 Sex disparities and female reproductive and hormonal factors associated with risk of pancreatic cancer in the european prospective investigation into cancer and nutrition (EPIC) cohort Katzke, Verena Dutta, Srimanti Rasokat, Anna Archibugi, Livia Capurso, Gabriele Peduzzi, Giulia Gentiluomo, Manuel Canzian, Federico Eriksen, Anne Kirstine Tjønneland, Anne Dahm, Christina C. Truong, Thérèse Canonico, Marianne Laouali, Nasser Schulze, Matthias B. Tumino, Rosario Masala, Giovanna Agnoli, Claudia Dansero, Lucia Panico, Salvatore Crous Bou, Marta Molina Montes, Esther Dorronsoro, Ane Chirlaque, María Dolores Guevara, Marcela Butt, Salma Tunå Sund, Malin Christakoudi, Sofia Aglago, Elom K. Weiderpass, Elisabete Gunter, Marc J. Campa, Daniele Kaaks, Rudolf Càncer de pàncrees Factors sexuals en les malalties Pancreas cancer Sex factors in disease Background/Objectives: Worldwide, men experience a higher incidence of pancreatic cancer (PC) than women. Methods: To increase understanding of the underlying reasons for this sex-related difference, we analysed general and sex-related risk factors for PC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (women/men No. = 293,682/136,728; 717/577 PC-cases). Results: Cox proportional hazards models showed a 1.31-fold higher risk of developing PC for men compared to women (HR, 95% CI 1.15-1.49) after adjustment for age, smoking history, BMI, diabetes, and alcohol consumption. Associations of PC with established risk factors did not differ between men and women, with the exception of a greater risk of PC among women with greater attained body height, meat consumption and cigarettes smoked (1.12 (1.05-1.19) per 5 cm, 1.18 (1.02-1.36) per 100 g/d, 1.42 (1.27-1.59) per 10/d; respectively). Among child-bearing women, long cumulative duration of breastfeeding was inversely associated with risk of PC (HR 0.74, 95% CI 0.61-0.89) for >5.7 months of breastfeeding (median) relative to <= 5.7 months and among HRT users, cumulative duration of HRT use was inversely associated with PC risk (HR 0.71, 95% CI 0.53-0.95, >2.4 versus <= 2.4 years). Further reproductive and hormonal factors, such as age at menarche, number of full-term pregnancies, age at menopause, or use of oral contraceptives, were not significantly associated with PC risk. Conclusions: Pooled analyses of large cohort studies are needed to confirm these results, and detailed data on the type and intensity of HRT are required to better evaluate its effect. 2025-08-29T12:07:49Z 2025-08-29T12:07:49Z 2025-07-08 2025-08-26T12:52:28Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.3390/cancers17142275 Cancers, 2025, vol. 17, num. 14, 2275 https://doi.org/10.3390/cancers17142275 cc-by (c) Katzke, Verena et al., 2025 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess MDPI Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))