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Frailty Prevalence and Characterization Among Kidney Transplant Candidates in Spain: A Multicenter Study Pérez Sáez, María José Melilli, Edoardo Arias, Marta Franco, Antonio Martínez, Rocío Sancho, Asunción Molina, María Facundo, Carme Polanco, Natalia López, Verónica Mazuecos, Auxiliadora Cabello, Sheila González García, María Elena Suárez, María Luisa Auyanet, Ingrid Espi, Jordi García Falcón, Teresa Ruiz, Juan Carlos Galeano, Cristina Artamendi, Marta Rodríguez Ferrero, María Luisa Portolés, José Santana, María Auxiliadora Martín Moreno, Paloma Leticia Arhda, Nisrine Calvo, Marta Mendiluce, Alicia Macía, Manuel Pérez Tamajón, María Lourdes Teresa, Javier de Gascó, Blanca Soriano, Sagrario Tabernero, Guadalupe Vara, Lourdes de la Ramos, Ana María Martínez, Rafael Montero de Espinosa, Enrique Zalve, José Luis Pascual, Julio (Pascual Santos) Rodríguez Mañas, Leocadio Gutiérrez Dalmau, Alex Moreso, Francesc Malalties del ronyó Trasplantament renal Kidney diseases Kidney transplantation Frailty is a frequent condition among kidney transplant candidates (KTc) that confers poor outcomes after transplantation. We aimed to establish frailty prevalence in a representative sample of KTc in Spain. We conducted a multicenter cross-sectional study including 1194 KTc >= 50 years. Frailty was assessed by the FRAIL scale. Mean age was 64.2 years; 38.4% were female. Median Charlson comorbidity index (CCI) was 6 [4-7] and the total number of medications was 9 [7-12]. We found that 8.2% of patients were frail and 41.5% were pre-frail. Frailty was more frequent among females (60.2% of frail vs. 32.8% of robust; p < 0.001), hemodialysis patients (74.5% of frail vs. 67.1% of robust; p = 0.02), and those with a high burden of disease (54.6% of frail patients with CCI >6 vs. 29.3% of robust; p < 0.001). The multivariable analysis confirmed that frailty was associated with the female sex (OR 3.9 [2.5-6.2]); higher CCI (>6 OR 2.9 [1.6-54]); and the number of medications (OR -per medication- 1.13 [1.07-1.2]). Almost 50% of KTc in Spain are pre-frail or frail. Frailty is more prevalent between women and patients with high comorbidity burden. Identifying those candidates at risk is essential to establish risks and implement strategies to minimize them. 2025-08-26T11:54:51Z 2025-08-26T11:54:51Z 2025-06-24 2025-08-19T08:09:07Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.3389/ti.2025.14098 Transplant International, 2025, vol. 38 https://doi.org/10.3389/ti.2025.14098 cc by (c) Pérez Sáez, María José et al, 2025 http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Frontiers Media SA Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))