2026-04-13T01:04:02Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2223352025-12-04T21:25:07Zcom_2072_1057col_2072_478779col_2072_478917

00925njm 22002777a 4500 dc Gabaldón Figueira, Juan Carlos author Ros Lucas, Albert author Martinez-Peinado, Nieves author Blackburn, Gavin author Losada Galvan, Irene author Posada, Elizabeth author Ballart Ferrer, J. Cristina author Escabia, Elisa author Capellades, Jordi author Yanes, Oscar author Pinazo, Maria-Jesus author Gascón i Brustenga, Joaquim author Alonso Padilla, Julio author 2025-07-17T11:56:18Z 2025-07-17T11:56:18Z 2024-11-09 2025-07-17T11:56:18Z Background: Chagas disease, caused by the parasite Trypanosoma cruzi, is a zoonosis that affects more than seven million people. Current limitations on the diagnosis of the disease hinder the prognosis of patients and the evaluation of treatment efficacy, slowing the development of new therapeutic options. The infection is known to disrupt several host metabolic pathways, providing an opportunity for the identification of biomarkers. Methods: The metabolomic and lipidomic profiles of a cohort of symptomatic and asymptomatic patients with T. cruzi infection and a group of uninfected controls were analysed using liquid chromatography/mass spectrometry. Differences among all groups and changes before and after receiving anti-parasitic treatment across those with T. cruzi infection were explored. Results: Three lipids were found to differentiate between symptomatic and asymptomatic participants: 10-hydroxydecanoic acid and phosphatidylethanolamines PE(18:0/20:4) and PE(18:1/20:4). Additionally, sphinganine, 4-hydroxysphinganine, hexadecasphinganine, and other sphingolipids showed post-treatment abundance similar to that in non-infected controls. Conclusions: These molecules hold promise as potentially useful biomarkers for monitoring disease progression and treatment response in patients with chronic T. cruzi infection. Malaltia de Chagas Protists Metabolòmica Esfingolípids Chagas' disease Protista Metabolomics Sphingolipids Changes in lipid abundance are associated with disease progression and treatment response in chronic Trypanosoma cruzi infection