2026-04-17T11:36:51Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2222572026-03-18T19:05:52Zcom_2072_1057col_2072_478798col_2072_478858col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Arroyo Huidobro, Marta author Pallarès, Natàlia author Tebé, Cristian author Simonetti, Antonella Francesca author Pérez-López, Carlos author Abelenda Alonso, Gabriela author Rombauts, Alexander author Bermudez, Isabel Oriol author Izquierdo, Elisenda author Díaz Brito, Vicens author Molist, Gemma author Gómez Melis, Guadalupe author Videla, Sebastià author López-Soto, Alfonso author Carratalà, Jordi author Rodriguez Molinero, Alejandro author 2025-07-15T10:38:02Z 2025-07-15T10:38:02Z 2024-10-19 2025-07-15T10:38:02Z Objective: This study aimed to describe the clinical presentation of COVID-19 in hospitalized patients aged 80 or above and to identify predictors for death and complications throughout the epidemic waves of the disease. Methods: This was an observational, multicenter, ambispective study conducted between March 2020 and August 2021 using data collected in five centers from southern metropolitan area of Barcelona (COVID-MetroSud cohort). Patients were grouped based on the pandemic waves of inclusion in the registry. We conducted a descriptive analysis, followed by bivariate and multivariate analyses (binary logistic regression) to identify predictors of risk for death or complications. Results: A total of 1192 patients (mean [SD] age 85.7 [4.22] years and 46.8% female) were included. The most frequently reported symptoms in all waves were fever (63.1%), cough (56.5%), dyspnea (48.2%), and asthenia (27.5%). Laboratory and radiological findings consistently showed abnormal bilateral chest X-ray results (72.5% of patients) and elevated inflammatory markers such as lactate dehydrogenase (mean [SD] 335 [188] U/L), C-reactive protein (CRP) (mean [SD] 110 [88.4] U/L), and ferritin (mean [SD] 842 [1561] U/L). Acute respiratory distress syndrome (43.7%), renal failure (19.2%), and delirium (17.5%) were the most frequent complications. The overall mortality rate was 41.4% and declined across the epidemic waves. Age, diabetes mellitus, heart failure, dyspnea, and higher baseline levels of creatinine were identified as risk factors for complications, while a higher Barthel index and presence of cough were found to be protective. Age, dyspnea, abnormal bilateral chest X-ray, CRP, and sodium were identified as risk factors for death. Conclusions: This study demonstrates the clinical presentation of COVID-19 (fever, cough, dyspnea, and asthenia) and the different risk factors for mortality and complications in octogenarian hospitalized patients throughout the pandemic. These findings could be highly valuable for managing future virus pandemics. Persones grans COVID-19 Factors de risc en les malalties Mortalitat Older people COVID-19 Risk factors in diseases Mortality Clinical characteristics and predictors of complications and mortality in hospitalized octogenarian patients with COVID-19: an ambispective study