2026-04-17T12:50:34Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/2222412025-12-05T14:19:42Zcom_2072_1057col_2072_478822col_2072_478902col_2072_478917
RECERCAT
author
Porro, Giulia Maria
author
Basile, Marco
author
Xie, Zhendong
author
Tuveri, Gianmarco
author
Battaglia, Giuseppe
author
Carvalho Ferreira Lopes, Cátia Daniela
2025-07-15T08:21:30Z2025-07-15T08:21:30Z2025-06-142025-07-15T07:28:24Z
Efficient drug delivery across the blood–brain barrier (BBB) remains a significant obstacle in treating central nervous system (CNS) disorders. This review provides an in-depth analysis of the structural and molecular mechanisms underlying BBB integrity and its functional properties. We detail the role of key cellular and molecular components that regulate selective molecular transport across the barrier, alongside a description of the current therapeutic approaches for brain drug delivery, including those leveraging receptor-mediated transcytosis. Emphasis is placed on multivalency-based strategies that enhance the specificity of nanoparticle targeting and improve transport efficacy across the BBB. Additionally, we discuss the added value of integrating mathematical and computational models with experimental validation for accelerating BBB-targeted delivery systems optimisation.
cc-by (c) Porro, Giulia Maria et al., 2025 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess
Neurofarmacologia
Farmacocinètica
Barrera hematoencefàlica
Neuropharmacology
Pharmacokinetics
Blood-brain barrier
A new era in brain drug delivery: Integrating multivalency and computational optimisation for blood–brain barrier permeation
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion