2026-04-14T02:11:22Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2222412025-12-05T14:19:42Zcom_2072_1057col_2072_478822col_2072_478902col_2072_478917

00925njm 22002777a 4500 dc Porro, Giulia Maria author Basile, Marco author Xie, Zhendong author Tuveri, Gianmarco author Battaglia, Giuseppe author Carvalho Ferreira Lopes, Cátia Daniela author 2025-07-15T08:21:30Z 2025-07-15T08:21:30Z 2025-06-14 2025-07-15T07:28:24Z Efficient drug delivery across the blood–brain barrier (BBB) remains a significant obstacle in treating central nervous system (CNS) disorders. This review provides an in-depth analysis of the structural and molecular mechanisms underlying BBB integrity and its functional properties. We detail the role of key cellular and molecular components that regulate selective molecular transport across the barrier, alongside a description of the current therapeutic approaches for brain drug delivery, including those leveraging receptor-mediated transcytosis. Emphasis is placed on multivalency-based strategies that enhance the specificity of nanoparticle targeting and improve transport efficacy across the BBB. Additionally, we discuss the added value of integrating mathematical and computational models with experimental validation for accelerating BBB-targeted delivery systems optimisation. Neurofarmacologia Farmacocinètica Barrera hematoencefàlica Neuropharmacology Pharmacokinetics Blood-brain barrier A new era in brain drug delivery: Integrating multivalency and computational optimisation for blood–brain barrier permeation