2026-04-13T06:00:28Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2215812025-11-20T15:00:02Zcom_2072_1057col_2072_478916col_2072_478917

Association Between Diagnostic Delay and Short-Term Outcomes in Patients with Radiographic Axial Spondyloarthritis: Results from the Regisponser-AS Registry Ladehesa Pineda, Lourdes Ruiz Vilchez, Desirée Barranco Moyano, Antonio Manuel Puche Larrubia, Maria Ángeles Font Ugalde, Pilar Granados, Raquel Ena María Gratacós Mastmija, Jordi Juanola, Xavier Escudero Contreras, Alejandro Collantes Estévez, Eduardo López Medina, Clementina Artritis Diagnòstic Arthritis Diagnosis Objectives: To evaluate whether the diagnostic delay in patients with radiographic axial spondyloarthritis (r-axSpA) is associated with poorer short-term outcomes after two years of follow-up. Methods: This was an observational, longitudinal, and prospective study including patients with r-axSpA from the national multicentre Spanish REGISPONSER-AS registry. Patients were divided into two groups according to the mean diagnostic delay (<5 years, >= 5 years). Binary logistic regression models adjusted for disease duration were constructed and used to evaluate the association between diagnostic delay and disease outcomes at two years. The retention rate for first-line treatment with anti-TNF across the groups was evaluated using a log-rank test. Results: A total of 565 patents were included. The mean diagnostic delay was 5.6 +/- 6.2 years, with 325 patients experiencing a delay of <5 years and 240 patients experiencing a delay of >= 5 years. A diagnostic delay of >= 5 years was associated, after 2 years, with a higher prevalence of inflammatory bowel disease (IBD) (OR 2.01 (95%CI 1.06-3.83)), a lower prevalence of synovitis (OR 0.68 (95%CI 0.47-0.98)) and dactylitis (OR 0.24 (95%CI 0.11-0.55)), and worse disease activity after adjusting by disease duration. However, no impact was observed on quality of life, structural damage, or work disability, probably due to the short follow-up period. Finally, no differences between the groups were found with regard to the retention rate for first-line anti-TNF treatment. Conclusions: Diagnostic delay is associated with poorer short-term outcomes in terms of structural damage, dactylitis, and disability in patients with r-axSpA. 2025-06-17T09:21:57Z 2025-06-17T09:21:57Z 2025-03-14 2025-06-06T09:58:45Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.3390/jcm14061977 Journal of Clinical Medicine, 2025, vol. 14, num. 6 https://doi.org/10.3390/jcm14061977 cc-by (c) Ladehesa Pineda et al., 2025 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess MDPI Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))