2026-04-14T06:47:31Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/2212692025-12-05T14:19:08Zcom_2072_1057col_2072_478902col_2072_478917
RECERCAT
author
Colleoni, Alessio
author
Galli, Giulia
author
Dallanoce, Clelia
author
Amici, Marco de
author
Gorostiza Langa, Pablo Ignacio
author
Matera, Carlo
2025-05-30T06:42:31Z2025-05-30T06:42:31Z2025-03-232025-05-21T12:48:04Z
Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to overcome the limitations of traditional drugs using photocleavable or photoswitchable ligands and spatiotemporal patterns of illumination. Spanning from muscarinic and nicotinic modulators to cholinesterase inhibitors, this review explores the development and application of light-activated compounds as tools for unraveling the role of cholinergic signaling in both physiological and pathological contexts, while also paving the way for innovative phototherapeutic approaches.
cc-by (c) Colleoni, Alessio et al., 2025 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess
Fotofarmacologia
Bioquímica
Receptors colinèrgics
Photopharmacology
Biochemistry
Acetylcholine receptors
Light-Activated Pharmacological Tools for Exploring the Cholinergic System
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion