2026-04-14T05:20:58Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2212692025-12-05T14:19:08Zcom_2072_1057col_2072_478902col_2072_478917

00925njm 22002777a 4500 dc Colleoni, Alessio author Galli, Giulia author Dallanoce, Clelia author Amici, Marco de author Gorostiza Langa, Pablo Ignacio author Matera, Carlo author 2025-05-30T06:42:31Z 2025-05-30T06:42:31Z 2025-03-23 2025-05-21T12:48:04Z Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to overcome the limitations of traditional drugs using photocleavable or photoswitchable ligands and spatiotemporal patterns of illumination. Spanning from muscarinic and nicotinic modulators to cholinesterase inhibitors, this review explores the development and application of light-activated compounds as tools for unraveling the role of cholinergic signaling in both physiological and pathological contexts, while also paving the way for innovative phototherapeutic approaches. Fotofarmacologia Bioquímica Receptors colinèrgics Photopharmacology Biochemistry Acetylcholine receptors Light-Activated Pharmacological Tools for Exploring the Cholinergic System