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oai:recercat.cat:2445/2209362025-12-05T15:55:50Zcom_2072_1057col_2072_478860col_2072_478917

Association between routine blood biomarkers and clinical phenotypes and exacerbations in chronic obstructive pulmonary disease Nuñez, Alexa Marras, Viviana Harlander, Matevz Mekov, Evgeni Esquinas López, Cristina Turel, Matjaz Lestan, David Petkov, Rosen Yanev, Nikolay Pirina, Pietro Negri, Silvia Miravitlles Fernández, Marc Barrecheguren, Miriam Marcadors bioquímics Malalties pulmonars obstructives cròniques Fenotip Biochemical markers Chronic obstructive pulmonary diseases Phenotype Introduction: Chronic obstructive pulmonary disease (COPD) is associated with increased lung and systemic inflammation. We aimed to identify associations between easy-to-obtain blood biomarkers and the frequency and severity of exacerbations. Methods: Cross-sectional, multicentre study performed in four centres in Spain, Italy, Bulgaria, and Slovenia. Blood samples were obtained for blood cell count, C-reactive protein (CRP), alpha-1 antitrypsin (AAT) and fibrinogen analysis. The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and eosinophil/basophil ratio (EBR) were calculated. Firstly, patients were divided into clinical phenotypes according to the Spanish guidelines of COPD, and secondly, patients were classified into 2 groups: non-exacerbators (≤1 ambulatory exacerbation in the previous year) and exacerbators (≥2 ambulatory exacerbations or 1 hospitalisation in the previous year). A multivariate stepwise logistic regression model was performed to identify laboratory parameters associated with exacerbators. Results: A total of 355 patients with a mean age 66 years (SD=8.9) were included, and 64% were male. The mean FEV1% (forced expiratory volume in the first second) was 55% (SD=20%), and the mean COPD Assessment Test (CAT) score was 15.6 (SD=7.9). One hundred ninety-six (55.2%) patients were classified in the non-exacerbator group, and 159 (44.8%) were exacerbators. Patients in the exacerbators group presented lower haemoglobin levels (p=0.019) and ERB (p= 0.023) but higher CRP levels (p=0.001). In the multivariate analysis, females, higher levels of CRP, lower FEV1% and low EBR were independently related to exacerbators. Conclusion: Female sex, having a more severe impairment of lung function, higher CRP levels and a lower EBR are associated with an exacerbator phenotype in COPD. 2025-05-09T17:46:50Z 2025-05-09T17:46:50Z 2020-03-31 2025-05-09T17:46:50Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.2147/COPD.S240720 International Journal of Chronic Obstructive Pulmonary Disease, 2020, vol. 15, p. 681-690 https://doi.org/10.2147/COPD.S240720 cc-by-nc (c) Nuñez, Alexa et al., 2020 http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess Dove Medical Press Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)