2026-04-17T16:15:00Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/2205302025-11-19T20:35:31Zcom_2072_1057col_2072_478796col_2072_478917
RECERCAT
author
Andrea Rincon-Lopez, July
author
Andrea Hermann-Munoz, Jennifer
author
Cinca i Luis, Núria
author
Andres Fernandez-Benavides, David
author
García Cano, Irene
author
Guilemany, J. M. (José María)
author
Boccaccini Aldo, Roberto
author
Munoz-Saldana, Juan
author
Alvarado-Orozco, Juan Manuel
2025-04-22T17:31:48Z2025-04-22T17:31:48Z2021-10-042025-04-22T17:31:48Z
The ability of the Nagelschmidtite (Nagel) phase to promote osteogenesis, cementogenesis, and angiogenesis increased the interest in using this calcium silicophosphate bioceramic for tissue regeneration and vasculariza tion applications. Nagel phase is a solid solution with the general formula Ca7-xNax(PO4)2+x(SiO4)2-x, which allows several substitutions being Ca7(PO4)2(SiO4)2 the most reported stoichiometry. Inspired by the well-known 45S5 bioactive glass chemical composition, we developed a synthesis route to obtain a Na-rich Nagel single phase. The effect of this bioceramic chemical and structural properties on apatite formation and crystallization mechanism is reported. The structural aspects at the nano and microscale of the mechanism of apatite growth and crystallization from the Nagel phase were compared to the formation process of Extra-Cellular Matrix (ECM) deposits in biological systems, revealing a biomimetic behavior during the apatite biomineralization process from the bioceramic.
cc-by-nc-nd (c) Elsevier B.V., 2021 http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess
Biomineralització
Microestructura
Ceràmica industrial
Biomineralization
Microstructure
Ceramics
Accelerated bioactive behavior of Nagelschmidtite bioceramics: Mimicking the nano and microstructural aspects of biological mineralization
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion