2026-04-18T01:40:15Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2205302025-11-19T20:35:31Zcom_2072_1057col_2072_478796col_2072_478917

00925njm 22002777a 4500 dc Andrea Rincon-Lopez, July author Andrea Hermann-Munoz, Jennifer author Cinca i Luis, Núria author Andres Fernandez-Benavides, David author García Cano, Irene author Guilemany, J. M. (José María) author Boccaccini Aldo, Roberto author Munoz-Saldana, Juan author Alvarado-Orozco, Juan Manuel author 2025-04-22T17:31:48Z 2025-04-22T17:31:48Z 2021-10-04 2025-04-22T17:31:48Z The ability of the Nagelschmidtite (Nagel) phase to promote osteogenesis, cementogenesis, and angiogenesis increased the interest in using this calcium silicophosphate bioceramic for tissue regeneration and vasculariza tion applications. Nagel phase is a solid solution with the general formula Ca7-xNax(PO4)2+x(SiO4)2-x, which allows several substitutions being Ca7(PO4)2(SiO4)2 the most reported stoichiometry. Inspired by the well-known 45S5 bioactive glass chemical composition, we developed a synthesis route to obtain a Na-rich Nagel single phase. The effect of this bioceramic chemical and structural properties on apatite formation and crystallization mechanism is reported. The structural aspects at the nano and microscale of the mechanism of apatite growth and crystallization from the Nagel phase were compared to the formation process of Extra-Cellular Matrix (ECM) deposits in biological systems, revealing a biomimetic behavior during the apatite biomineralization process from the bioceramic.   Biomineralització Microestructura Ceràmica industrial Biomineralization Microstructure Ceramics Accelerated bioactive behavior of Nagelschmidtite bioceramics: Mimicking the nano and microstructural aspects of biological mineralization