2026-04-05T10:52:52Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2204972025-11-20T14:56:17Zcom_2072_1057col_2072_478916col_2072_478917

Biomarkers of Oxidation, Inflammation and Intestinal Permeability in Persons with Diabetes Mellitus with Parenteral Nutrition: a Multicenter Randomized Trial Soria Utrilla, Virginia Sasso, Corina Verónica Romero Zerbo, Silvana Yanina Adarve Castro, Antonio López Urdiales, Rafael Herranz Antolín, Sandra García Almeida, José Manuel García Malpartida, Katherine Ferrer Gómez, Mercedes Moreno Borreguero, Alicia Luengo Pérez, Luis Miguel Álvarez Hernández, Julia Aragón Valera, Carmen Ocón Bretón, María Julia García Manzanares, Álvaro Bretón Lesmes, Irene Serrano Aguayo, Pilar Pérez Ferre, Natalia López Gómez, Juan José Olivares Alcolea, Josefina Moreno Martínez, Macarena Tejera Pérez, Cristina García Arias, Sara Abad González, Ángel Luis Alhambra Expósito, María Rosa Zugasti Murillo, Ana Parra Barona, Juan Torrejón Jaramillo, Sara Abuin, José Fernández García, José Carlos Olveira, Gabriel the Nutrition Area of the Spanish Society of Endocrinology and Nutrition (SEEN) Permeabilitat Intestins Diabetis no-insulinodependent Marcadors bioquímics Permeability Intestines Non-insulin-dependent diabetes Biochemical markers Background and aims: Parenteral nutrition (PN) composition could play a role in the management of systemic inflammatory response and intestinal barrier disruption. We aimed to evaluate changes in biomarkers of inflammation, oxidative status and intestinal permeability in patients with type 2 diabetes mellitus (T2DM) who received different PN lipid formulas. Methods: This was a prospective study, including 94 patients with T2DM who received omega (n)-3 polyunsaturated fatty acids (PUFA)-enriched PN, a mixture of medium and long chain triglycerides (MCT/ LCT) PN, or an olive oil-based PN. Serum levels of biomarkers of oxidative status, intestinal permeability and inflammation biomarkers were determined at day 1 and day 5 after PN initiation. Registered under ClinicalTrials.gov Identifier no. NCT02706119. Results: At day 5 after the onset of PN, the MCT/LCT group had a significant reduction of 2 proinflammatory cytokines [interleukin (IL)-15, IL-17A], elevation of the anti-inflammatory cytokine IL-13 and increase of zonulin and indoxylsulfate. The olive oil group showed a statistically significant reduction of 5 proinflammatory cytokines [IL-1D, IL-17A, IL-6, cytokine-leukemia inhibitory factor (LIF) and tumor necrosis factor alpha (TNF-a)] and reduced concentrations of the anti-inflammatory cytokine IL-1RA, while the n-3 PUFA-enriched group presented a statistically significant reduction of 8 proinflammatory cytokines (interferon-gamma, IL-1D, IL-15, IL-17A, IL-6, LIF, monocyte chemoattractant protein 1, and TNF-a). In the between-group comparisons, indoxylsulfate significantly increased in the MCT/LCT group compared to the n-3 PUFA-enriched group, while 8-isoprostane and indoxylsulfate significantly increased in the MCT/LCT group compared to the other groups and superoxide dismutase significantly decreased in the MCT/LCT group compared to the other groups. Conclusion: In patients with T2DM, PN lipid composition exerts a profound impact on proinflammatory, prooxidative and intestinal permeability biomarkers. 2025-04-16T09:36:01Z 2025-04-16T09:36:01Z 2025-01-01 2025-04-03T11:59:06Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.1016/j.clnu.2024.11.044 Clinical Nutrition, 2025, vol. 44, p. 155-164 https://doi.org/10.1016/j.clnu.2024.11.044 cc-by-nc-nd (c) Soria Utrilla, Virginia et al., 2024 http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess Elsevier BV Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))