2026-04-13T07:20:30Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2204972025-11-20T14:56:17Zcom_2072_1057col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Soria Utrilla, Virginia author Sasso, Corina Verónica author Romero Zerbo, Silvana Yanina author Adarve Castro, Antonio author López Urdiales, Rafael author Herranz Antolín, Sandra author García Almeida, José Manuel author García Malpartida, Katherine author Ferrer Gómez, Mercedes author Moreno Borreguero, Alicia author Luengo Pérez, Luis Miguel author Álvarez Hernández, Julia author Aragón Valera, Carmen author Ocón Bretón, María Julia author García Manzanares, Álvaro author Bretón Lesmes, Irene author Serrano Aguayo, Pilar author Pérez Ferre, Natalia author López Gómez, Juan José author Olivares Alcolea, Josefina author Moreno Martínez, Macarena author Tejera Pérez, Cristina author García Arias, Sara author Abad González, Ángel Luis author Alhambra Expósito, María Rosa author Zugasti Murillo, Ana author Parra Barona, Juan author Torrejón Jaramillo, Sara author Abuin, José author Fernández García, José Carlos author Olveira, Gabriel author the Nutrition Area of the Spanish Society of Endocrinology and Nutrition (SEEN) author 2025-04-16T09:36:01Z 2025-04-16T09:36:01Z 2025-01-01 2025-04-03T11:59:06Z Background and aims: Parenteral nutrition (PN) composition could play a role in the management of systemic inflammatory response and intestinal barrier disruption. We aimed to evaluate changes in biomarkers of inflammation, oxidative status and intestinal permeability in patients with type 2 diabetes mellitus (T2DM) who received different PN lipid formulas. Methods: This was a prospective study, including 94 patients with T2DM who received omega (n)-3 polyunsaturated fatty acids (PUFA)-enriched PN, a mixture of medium and long chain triglycerides (MCT/ LCT) PN, or an olive oil-based PN. Serum levels of biomarkers of oxidative status, intestinal permeability and inflammation biomarkers were determined at day 1 and day 5 after PN initiation. Registered under ClinicalTrials.gov Identifier no. NCT02706119. Results: At day 5 after the onset of PN, the MCT/LCT group had a significant reduction of 2 proinflammatory cytokines [interleukin (IL)-15, IL-17A], elevation of the anti-inflammatory cytokine IL-13 and increase of zonulin and indoxylsulfate. The olive oil group showed a statistically significant reduction of 5 proinflammatory cytokines [IL-1D, IL-17A, IL-6, cytokine-leukemia inhibitory factor (LIF) and tumor necrosis factor alpha (TNF-a)] and reduced concentrations of the anti-inflammatory cytokine IL-1RA, while the n-3 PUFA-enriched group presented a statistically significant reduction of 8 proinflammatory cytokines (interferon-gamma, IL-1D, IL-15, IL-17A, IL-6, LIF, monocyte chemoattractant protein 1, and TNF-a). In the between-group comparisons, indoxylsulfate significantly increased in the MCT/LCT group compared to the n-3 PUFA-enriched group, while 8-isoprostane and indoxylsulfate significantly increased in the MCT/LCT group compared to the other groups and superoxide dismutase significantly decreased in the MCT/LCT group compared to the other groups. Conclusion: In patients with T2DM, PN lipid composition exerts a profound impact on proinflammatory, prooxidative and intestinal permeability biomarkers. Permeabilitat Intestins Diabetis no-insulinodependent Marcadors bioquímics Permeability Intestines Non-insulin-dependent diabetes Biochemical markers Biomarkers of Oxidation, Inflammation and Intestinal Permeability in Persons with Diabetes Mellitus with Parenteral Nutrition: a Multicenter Randomized Trial