2026-04-18T04:31:11Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/2188062025-12-04T19:31:23Zcom_2072_1057col_2072_478908col_2072_478917col_2072_478933
RECERCAT author Rojo, Pep author Riera i Escalé, Antoni author Verdaguer i Espaulella, Xavier 2025-02-14T18:42:33Z2025-02-14T18:42:33Z2023-04-212025-02-14T18:42:34Z Since the development of BisP* ligand by Imamoto, P-stereogenic phosphines bearing a bulky tert-butyl group and a smaller alkyl group have demonstrated extraordinary proficiency in a wide range of asymmetric processes. Over time, this class of ligands has brought about the introduction of more rigid backbones, the three-hindered quadrant concept, and the substitution of the tert-butyl group by adamantyl. The tert-butyl methyl fragment has also been introduced in phosphino-oxazoline-type ligands, and chemists in the industrial sector have also contributed to the evolution of this class of ligands by reporting the first successful P-stereogenic Buchwald-type monophosphines for asymmetric coupling reactions. The present review covers the synthesis and applications of bulky P-stereogenic phosphines that have been developed since the advent of BisP* in the late 1990s, with a special emphasis on ligands that have been successfully applied in asymmetric catalysis. cc-by-nc-nd (c) Rojo, Pep, et al., 2023 http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Oxidació Catàlisi Quiralitat Oxidation Catalysis Chirality Bulky P-stereogenic ligands. A success story in asymmetric catalysis info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion