2026-04-14T03:57:33Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/2186682025-11-20T13:50:24Zcom_2072_1057col_2072_478799col_2072_478917
RECERCAT
author
Rullo Tubau, Josep
author
Bartoccioni, Paola
author
Llorca, Oscar
author
Errasti-Murugarren, Ekaitz
author
Palacín Prieto, Manuel
2025-02-11T15:20:47Z2025-02-11T15:20:47Z2022-06-012025-02-11T15:20:47Z
Heteromeric amino acid transporters (HATs) are one of the ten types of amino acid transporters present in the human body. Growing interest in the pathophysiological role of this group of transporters in rare and complex diseases and cancer has brought about the recent resolution of various structures of human HATs and bacterial homologues at atomic level. This knowledge sheds light on the mechanisms of transport used by these molecules. Here, we discuss the molecular bases underlying substrate specificity, binding asymmetry, and the impact of disease-causing mutations on transporter biogenesis and function.
cc-by-nc-nd (c) Current Opinion, 2022 http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess
Transport biològic
Biologia molecular
Aminoàcids
Biological transport
Molecular biology
Amino acids
HATs meet structural biology
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion