2026-04-14T09:23:57Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2186682025-11-20T13:50:24Zcom_2072_1057col_2072_478799col_2072_478917

00925njm 22002777a 4500 dc Rullo Tubau, Josep author Bartoccioni, Paola author Llorca, Oscar author Errasti-Murugarren, Ekaitz author Palacín Prieto, Manuel author 2025-02-11T15:20:47Z 2025-02-11T15:20:47Z 2022-06-01 2025-02-11T15:20:47Z Heteromeric amino acid transporters (HATs) are one of the ten types of amino acid transporters present in the human body. Growing interest in the pathophysiological role of this group of transporters in rare and complex diseases and cancer has brought about the recent resolution of various structures of human HATs and bacterial homologues at atomic level. This knowledge sheds light on the mechanisms of transport used by these molecules. Here, we discuss the molecular bases underlying substrate specificity, binding asymmetry, and the impact of disease-causing mutations on transporter biogenesis and function. Transport biològic Biologia molecular Aminoàcids Biological transport Molecular biology Amino acids HATs meet structural biology