2026-04-14T06:31:00Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2181752025-12-04T22:32:31Zcom_2072_1057col_2072_478906col_2072_478917col_2072_478931

00925njm 22002777a 4500 dc Adan Puig, Ana author Marquez Arrico, Julia E. author Río Martínez, Laura author Navarro, José Francisco author Martinez Nicolas, Antonio author 2025-01-29T16:33:40Z 2025-01-29T16:33:40Z 2024 2025-01-29T16:33:40Z Circadian rhythmicity is associated to clinical variables that play an important role in both schizophrenia (SZ) and substance use disorders (SUD), although the characteristics of the coexistence of these two diagnoses (SZ +) remain mostly unknown. Hence, we studied a sample of 165 male patients divided in three groups each of 55, according to their diagnoses (SZ + , SZ, and SUD), as well as a healthy control (HC; n = 90) group. Alongside with sociodemographic and clinical variables, circadian rhythms were registered through a sleep–wake data structured interview, a circadian typology questionnaire, and distal skin temperature (DST) using the Thermochron iButton every 2 min during 48 h. Analyses showed that SZ + and SZ patients presented a longer sleep (delay in wake-up time) and mostly an intermediate circadian typology, while SUD patients slept less hours, displaying a morning typology. The DST showed the highest daily activation and stability for the SUD group, even when compared with the HC group. The presence of schizophrenia (SZ + and SZ) was related to a DST pattern with a reduced amplitude determined by a wakefulness impairment, which was more pronounced for SZ patients whose sleep period was adequate. The assessment of circadian rhythms in under treatment male patients with SZ should be focused on the diurnal period as a possible marker of either treatment adherence or patient's recovery, irrespective of the presence of a comorbid SUD. Further research with additional objective measures may provide knowledge transferable to therapeutic strategies and could be useful to establish possible endophenotypes in the future. Esquizofrènia Ritmes circadiaris Homes Abús de substàncies Schizophrenia Circadian rhythms Men Substance abuse Circadian rhythmicity in schizophrenia male patients with and without substance use disorder comorbidity