2026-04-13T02:21:41Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/2165432025-12-05T14:48:31Zcom_2072_1057col_2072_478821col_2072_478917
RECERCAT
author
Gouveia, Virginia M.
author
Rizzello, Loris
author
Nunes, C.
author
Poma, Alessandro
author
Ruiz-Perez, Lorena
author
Oliveira, A.
author
Reis, S.
author
Battaglia, Giuseppe
2024-11-16T10:04:45Z2024-11-16T10:04:45Z2019-11-152024-11-16T10:04:45Z
Glucocorticoid (GC) drugs are the cornerstone therapy used in the treatment of inflammatory diseases. Here, we report pH responsive poly(2-methacryloyloxyethyl phosphorylcholine)–poly(2-(diisopropylamino)ethyl methacrylate) (PMPC–PDPA) polymersomes as a suitable nanoscopic carrier to precisely and controllably deliver GCs within inflamed target cells. The in vitro cellular studies revealed that polymersomes ensure the stability, selectivity and bioavailability of the loaded drug within macrophages. At molecular level, we tested key inflammation-related markers, such as the nuclear factor-κB, tumour necrosis factor-α, interleukin-1β, and interleukin-6. With this, we demonstrated that pH responsive polymersomes are able to enhance the anti-inflammatory effect of loaded GC drug. Overall, we prove the potential of PMPC–PDPA polymersomes to efficiently promote the inflammation shutdown, while reducing the well-known therapeutic limitations in GC-based therapy.
cc-by (c) Gouveia, V.M. et al., 2019 http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
Inflamació
Glucocorticoides
Macròfags
Inflammation
Glucocorticoids
Macrophages
Macrophage Targeting pH Responsive Polymersomes for Glucocorticoid Therapy<br />
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion