2026-04-14T05:29:56Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/2161592025-12-04T19:30:40Zcom_2072_1057col_2072_478908col_2072_478917
RECERCAT
author
Pascual, Gloria
author
Aznar Benitah, Salvador
2024-10-31T13:53:30Z2024-10-31T13:53:30Z2024-09-262024-10-31T12:42:39Z
Tumor cells can undergo metabolic adaptations that support their growth, invasion,
and metastasis, such as reprogramming lipid metabolism to meet their energy
demands and to promote survival in harsh microenvironmental conditions,
including hypoxia and acidification. Metabolic rewiring, and especially alterations in
lipid metabolism, not only fuel tumor progression but also influence immune cell
behavior within the tumor microenvironment (TME), leading to immunosuppression
and immune evasion. These processes, in turn, may contribute to the metastatic
spread of cancer. The diverse metabolic profiles of immune cell subsets, driven by
the TME and tumor-derived signals, contribute to the complex immune landscape in
tumors, affecting immune cell activation, differentiation, and effector functions.
Understanding and targeting metabolic heterogeneity among immune cell subsets
will be crucial for developing effective cancer immunotherapies that can overcome
immune evasion mechanisms and enhance antitumor immunity.
cc by (c) Pascual, Gloria et al., 2024 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess
Tumors
Lípids
Tumors
Lipids
Lipids in the tumor microenvironment: immune modulation and metastasis
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion