2026-04-03T20:28:38Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2159712025-12-04T21:16:34Zcom_2072_1057col_2072_478781col_2072_478917

00925njm 22002777a 4500 dc Bosch de Basea, Laia author Boguñà, Marina author Sánchez, Alicia author Esteve Ràfols, Montserrat author Grasa Martínez, Maria del Mar author Romero Romero, María del Mar author 2024-10-22T17:04:16Z 2024-10-22T17:04:16Z 2024-04-01 2024-10-22T17:04:16Z Recently, intermittent fasting has gained relevance as a strategy to lose weight and improve health as an alternative to continuous caloric restriction. However, the metabolic impact and the sex-related differences are not fully understood. The study aimed to compare the response to a continuous or intermittent caloric restriction in male and female rats following a previous induction of obesity through a cafeteria diet by assessing changes in body weight, energy intake, metabolic parameters, and gene expression in liver hepatic and adipose tissue. The continuous restriction reduced the energy available by 30% and the intermittent restriction consisted of a 75% energy reduction on two non-consecutive days per week. The interventions reduced body weight and body fat in both sexes, but the loss of WAT in females was more marked in both models of caloric restriction, continuous and intermittent. Both caloric restrictions improved insulin sensitivity, but more markedly in females, which showed a more pronounced decrease in HOMA-IR score and an upregulation of hepatic IRS2 and Sirt1 gene expression that was not observed in males. These findings suggest the fact that females are more sensitive than males to reduced caloric content in the diet. Dietes d'aprimament Resistència a la insulina Reducing diets Insulin resistance Sex-Dependent Metabolic Effects in Diet-Induced Obese Rats following Intermittent Fasting Compared with Continuous Food Restriction