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urn:hdl:2445/215920 Proximity-induced pharmacology for amyloid-related diseases<br /> Bertran-Mostazo, Andrea Putriute, Gabrielé Álvarez-Berbel, Irene Busquets i Viñas, Ma. Antonia Galdeano Cantador, Carlos Espargaró Colomé, Alba Sabaté Lagunas, Raimon Malalties neurodegeneratives Amiloïdosi Disseny de medicaments Neurodegenerative Diseases Amyloidosis Drug design <p>Proximity-induced pharmacology (PIP) for amyloid-related diseases is a cutting-edge</p><p>approach to treating conditions such as Alzheimer’s disease and other forms of dementia. By bringing</p><p>small molecules close to amyloid-related proteins, these molecules can induce a plethora of effects</p><p>that can break down pathogenic proteins and reduce the buildup of plaques. One of the most</p><p>promising aspects of this drug discovery modality is that it can be used to target specific types of</p><p>amyloid proteins, such as the beta-amyloid protein that is commonly associated with Alzheimer’s</p><p>disease. This level of specificity could allow for more targeted and effective treatments. With ongoing</p><p>research and development, it is hoped that these treatments can be refined and optimized to provide</p><p>even greater benefits to patients. As our understanding of the underlying mechanisms of these</p><p>diseases continues to grow, proximity-induced pharmacology treatments may become an increasingly</p><p>important tool in the fight against dementia and other related conditions.</p> 2024-10-21T10:49:16Z 2024-10-21T10:49:16Z 2024-03-04 2024-10-21T10:49:16Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.3390/cells13050449 Cells, 2024, vol. 13 https://doi.org/10.3390/cells13050449 cc-by (c) Bertran-Mostazo, A. et al., 2024 http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess MDPI Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)