2026-04-13T03:12:53Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2156622025-12-05T14:19:17Zcom_2072_1057col_2072_478902col_2072_478917col_2072_478933

00925njm 22002777a 4500 dc Gomila, Alexandre MJ author Rustler, Karin author Maleeva, Galyna author Nin-Hill, Alba author Wutz, Daniel author Bautista-Barrufet, Antoni author Rovira, Xavier author Bosch, Miquel author Mukhametova, Elvira author Petukhova, Elena author Ponomareva, Daria author Mukhamedyarov, Marat author Peiretti, Franck author Alfonso Prieto, Mercedes author Rovira i Virgili, Carme author König, Burkhard author Bregestovski, Piotr author Gorostiza, Pau author 2024-10-10T14:14:28Z 2024-10-10T14:14:28Z 2020-11-19 2024-10-10T14:14:28Z Glycine receptors (GlyRs) are indispensable for maintaining excitatory/inhibitory balance in neuronal circuits that control reflexes and rhythmic motor behaviors. Here we have developed Glyght, a GlyR ligand controlled with light. It is selective over other Cys-loop receptors, is active in vivo, and displays an allosteric mechanism of action. The photomanipulation of glycinergic neurotransmission opens new avenues to understanding inhibitory circuits in intact animals and to developing drug-based phototherapies. Fotoquímica Fotofarmacologia Photochemistry Photopharmacology Photocontrol of endogenous glycine receptors in vivo