2026-04-13T05:55:50Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2156622025-12-05T14:19:17Zcom_2072_1057col_2072_478902col_2072_478917col_2072_478933

urn:hdl:2445/215662 Photocontrol of endogenous glycine receptors in vivo Gomila, Alexandre MJ Rustler, Karin Maleeva, Galyna Nin-Hill, Alba Wutz, Daniel Bautista-Barrufet, Antoni Rovira, Xavier Bosch, Miquel Mukhametova, Elvira Petukhova, Elena Ponomareva, Daria Mukhamedyarov, Marat Peiretti, Franck Alfonso Prieto, Mercedes Rovira i Virgili, Carme König, Burkhard Bregestovski, Piotr Gorostiza, Pau Fotoquímica Fotofarmacologia Photochemistry Photopharmacology Glycine receptors (GlyRs) are indispensable for maintaining excitatory/inhibitory balance in neuronal circuits that control reflexes and rhythmic motor behaviors. Here we have developed Glyght, a GlyR ligand controlled with light. It is selective over other Cys-loop receptors, is active in vivo, and displays an allosteric mechanism of action. The photomanipulation of glycinergic neurotransmission opens new avenues to understanding inhibitory circuits in intact animals and to developing drug-based phototherapies. 2024-10-10T14:14:28Z 2024-10-10T14:14:28Z 2020-11-19 2024-10-10T14:14:28Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.1016/j.chembiol.2020.08.005 Cell Chemical Biology, 2020, vol. 27, p. 1425-1433 https://doi.org/10.1016/j.chembiol.2020.08.005 cc-by-nc-nd (c) Gomila, Alexandre MJ, et al., 2020 http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Elsevier Inc. Articles publicats en revistes (Química Inorgànica i Orgànica)