2026-04-03T20:16:42Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/2145312025-12-05T14:19:31Zcom_2072_1057col_2072_478916col_2072_478902col_2072_478917col_2072_478929
RECERCAT author Ortega, J. Alberto author Soares De Aguiar, Gisele P. author Chandravanshi, Palash author Levy, Natacha author Engel López, Elisabeth author Álvarez, Zaida 2024-07-11T15:05:08Z2024-07-11T15:05:08Z2024-05-012024-06-25T09:16:45Z The extracellular matrix (ECM) is a dynamic and complex network of proteins and molecules that surrounds cells and tissues in the nervous system and orchestrates a myriad of biological functions. This review carefully examines the diverse interactions between cells and the ECM, as well as the transformative chemical and physical changes that the ECM undergoes during neural development, aging, and disease. These transformations play a pivotal role in shaping tissue morphogenesis and neural activity, thereby influencing the functionality of the central nervous system (CNS). In our comprehensive review, we describe the diverse behaviors of the CNS ECM in different physiological and pathological scenarios and explore the unique properties that make ECM-based strategies attractive for CNS repair and regeneration. Addressing the challenges of scalability, variability, and integration with host tissues, we review how advanced natural, synthetic, and combinatorial matrix approaches enhance biocompatibility, mechanical properties, and functional recovery. Overall, this review highlights the potential of decellularized ECM as a powerful tool for CNS modeling and regenerative purposes and sets the stage for future research in this exciting field. This article is categorized under: Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease Implantable Materials and Surgical Technologies > Nanomaterials and Implants cc by (c) Ortega, J. Alberto et al., 2024 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Sistema nerviós central Matriu extracel·lular Central nervous system Extracellular matrix Exploring the properties and potential of the neural extracellular matrix for next‐generation regenerative therapies info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion